Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea.
Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea.
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DOI：
10.3390/ijms241713094
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发表时间：
2023-08-23
影响因子：
5.6
通讯作者：
Baker, Sarah E.
中科院分区：
文献类型：
--
作者：
Bock, Joshua M.;Greenlund, Ian M.;Somers, Virend K.;Baker, Sarah E.
患有阻塞性睡眠呼吸暂停（OSA）的患者患心血管疾病（即高血压）的风险较高。虽然开创性证据表明交感神经活动在 OSA 患者常见的高血压表型中具有因果作用，但没有研究调查该人群中交感神经调节血压的潜在性别差异。支持这一探索的是大规模观察数据以及对健康成年人的对照干预研究，表明相对于男性，睡眠中断会在更大程度上增加女性的血压。此外，患有严重 OSA 的女性在快速动眼睡眠期间（当交感神经活动最强时）表现出更明显的缺氧负担（即疾病严重程度）。这些发现表明，女性因 OSA 和相关睡眠中断造成血流动力学后果的风险更大。因此，本综述的目的有三个：（1）回顾将交感神经活动与 OSA 高血压联系起来的文献，（2）强调支持 OSA 交感神经活动调节中性别差异假设的最新实验数据，以及（3）讨论外周肾上腺素信号传导中可能导致或抵消 OSA 患者心血管风险的潜在性别差异。
Patients with obstructive sleep apnea (OSA) have a heightened risk of developing cardiovascular diseases, namely hypertension. While seminal evidence indicates a causal role for sympathetic nerve activity in the hypertensive phenotype commonly observed in patients with OSA, no studies have investigated potential sex differences in the sympathetic regulation of blood pressure in this population. Supporting this exploration are large-scale observational data, as well as controlled interventional studies in healthy adults, indicating that sleep disruption increases blood pressure to a greater extent in females relative to males. Furthermore, females with severe OSA demonstrate a more pronounced hypoxic burden (i.e., disease severity) during rapid eye movement sleep when sympathetic nerve activity is greatest. These findings would suggest that females are at greater risk for the hemodynamic consequences of OSA and related sleep disruption. Accordingly, the purpose of this review is three-fold: (1) to review the literature linking sympathetic nerve activity to hypertension in OSA, (2) to highlight recent experimental data supporting the hypothesis of sex differences in the regulation of sympathetic nerve activity in OSA, and (3) to discuss the potential sex differences in peripheral adrenergic signaling that may contribute to, or offset, cardiovascular risk in patients with OSA.
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影响因子：
20.1
作者：
FREEDMAN, RR;SABHARWAL, SC;DESAI, N
通讯作者：
DESAI, N
影响因子：
7.5
作者：
Bonsignore, Maria R.;Saaresranta, Tarja;Riha, Renata L.
通讯作者：
Riha, Renata L.
影响因子：
8.3
作者：
Cappuccio, Francesco P.;Stranges, Saverio;Marmot, Michael G.
通讯作者：
Marmot, Michael G.
影响因子：
3.3
作者：
Bock, Joshua M.;Hanson, Brady E.;Casey, Darren P.
通讯作者：
Casey, Darren P.
影响因子：
2.7
作者：
Breskovic, Toni;Steinback, Craig D.;Dujic, Zeljko
通讯作者：
Dujic, Zeljko