Increased dynamic flexibility in the medial temporal lobe network following an exercise intervention mediates generalization of prior learning.
Increased dynamic flexibility in the medial temporal lobe network following an exercise intervention mediates generalization of prior learning.
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运动干预后，内侧颞叶网络中的动态灵活性提高了先前学习的概括。
DOI：
10.1016/j.nlm.2020.107340
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发表时间：
2021-01
影响因子：
2.7
通讯作者：
Gluck MA
中科院分区：
文献类型：
--
作者：
Sinha N;Berg CN;Yassa MA;Gluck MA
最近的研究将大脑概念化为一个由子网络或模块组成的网络。脑网络的“灵活性”是指组成模块的动态重构。本研究利用动态网络神经科学的新技术应用于高分辨率静息状态功能磁共振成像（fMRI），研究了有氧运动干预对内侧颞叶（MTL）网络内模块化社区结构（神经灵活性的衡量指标）动态重排的影响。MTL是最早受阿尔茨海默病影响的大脑区域之一。它也是神经可塑性的主要部位，对运动的影响很敏感。在一项包含34名健康老年人的两组非随机、重复测量和匹配对照设计中，我们观察到与运动相关的MTL网络灵活性的增加。此外，MTL网络灵活性介导有氧运动对记忆灵活性的有益影响，这是通过将过去的学习推广到新任务需求的能力来衡量的。我们的研究结果表明，运动对MTL功能具有康复和保护作用，导致在复杂的通信模式中相互作用的区域网络动态演变。这些重新配置可能是运动诱导的泛化认知测量改善的基础，这对MTL的细微变化很敏感。
Recent work has conceptualized the brain as a network comprised of groups of sub-networks or modules. “Flexibility” of brain network(s) indexes the dynamic reconfiguration of comprising modules. Using novel techniques from dynamic network neuroscience applied to high-resolution resting-state functional magnetic resonance imaging (fMRI), the present study investigated the effects of an aerobic exercise intervention on the dynamic rearrangement of modular community structure—a measure of neural flexibility—within the medial temporal lobe (MTL) network. The MTL is one of the earliest brain regions impacted by Alzheimer’s disease. It is also a major site of neuroplasticity that is sensitive to the effects of exercise. In a two-group non-randomized, repeated measures and matched control design with 34 healthy older adults, we observed an exercise-related increase in flexibility within the MTL network. Furthermore, MTL network flexibility mediated the beneficial effect aerobic exercise had on mnemonic flexibility, as measured by the ability to generalize past learning to novel task demands. Our results suggest that exercise exerts a rehabilitative and protective effect on MTL function, resulting in dynamically evolving networks of regions that interact in complex communication patterns. These reconfigurations may underlie exercise-induced improvements on cognitive measures of generalization, which are sensitive to subtle changes in the MTL.
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影响因子：
4.8
作者：
Chen X;Zhang H;Zhang L;Shen C;Lee SW;Shen D
通讯作者：
Shen D
影响因子：
--
作者：
Corbie-Smith, G;Thomas, SB;St George, DMM
通讯作者：
St George, DMM
影响因子：
4.8
作者：
Baniqued PL;Gallen CL;Voss MW;Burzynska AZ;Wong CN;Cooke GE;Duffy K;Fanning J;Ehlers DK;Salerno EA;Aguiñaga S;McAuley E;Kramer AF;D'Esposito M
通讯作者：
D'Esposito M
影响因子：
3.9
作者：
Ferman, TJ;Lucas, JA;Graff-Radford, NR
通讯作者：
Graff-Radford, NR
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.