Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults.
Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults.
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DOI：
10.3389/fnagi.2017.00426
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发表时间：
2017
影响因子：
4.8
通讯作者：
D'Esposito M
中科院分区：
文献类型：
--
作者：
Baniqued PL;Gallen CL;Voss MW;Burzynska AZ;Wong CN;Cooke GE;Duffy K;Fanning J;Ehlers DK;Salerno EA;Aguiñaga S;McAuley E;Kramer AF;D'Esposito M
近期的研究表明，大脑可被概念化为一个由子网络群或模块组成的网络。模块之间的分离程度可用模块性度量来量化，模块性高的网络在模块内部有密集连接，而模块之间的连接则较为稀疏。先前的研究表明，在创伤性脑损伤患者以及健康的老年人和年轻人中，较高的模块性预示着认知训练后会有更大的改善。然而，尚不清楚模块性是否也能预测体育锻炼干预后的认知提升。在此，我们对老年人（N = 128，平均年龄 = 64.74岁）的模块性进行了量化，这些老年人接受了以下一种干预措施，为期6个月（ClinicalTrials.gov上的NCT01472744）：（1）以快走形式进行的有氧运动（步行组），（2）以快走形式进行的有氧运动加上营养补充剂（步行 + 组），（3）拉伸、强化和稳定性训练（SSS组），或（4）舞蹈教学（舞蹈组）。干预后，步行组、步行 + 组和SSS组在心肺适能（CRF）方面有所提高，与SSS组和舞蹈组相比，两个步行组的效果更明显。步行组、步行 + 组和SSS组在执行功能（EF）方面也有所改善，这是通过推理、工作记忆和任务转换测试来衡量的。在执行功能有所改善的步行组、步行 + 组和SSS组中，即使在控制了年龄、扫描时的运动以及基线执行功能之后，较高的基线模块性与执行功能的提升呈正相关。在舞蹈组中未观察到模块性与执行功能提升之间的关系，该组在心肺适能或执行功能控制方面未显示出与训练相关的提升。这些结果与先前的研究一致，先前的研究表明，大脑网络组织模块性更强的个体对认知训练的反应更好。这些发现表明，模块性的预测能力可能适用于旨在提高认知各方面的各种干预措施，并且特别是在表现较差的个体中，整体网络特性能够捕捉神经可塑性的个体差异。
Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules. Previous work has shown that higher modularity predicts greater improvements after cognitive training in patients with traumatic brain injury and in healthy older and young adults. It is not known, however, whether modularity can also predict cognitive gains after a physical exercise intervention. Here, we quantified modularity in older adults (N = 128, mean age = 64.74) who underwent one of the following interventions for 6 months (NCT01472744 on ClinicalTrials.gov): (1) aerobic exercise in the form of brisk walking (Walk), (2) aerobic exercise in the form of brisk walking plus nutritional supplement (Walk+), (3) stretching, strengthening and stability (SSS), or (4) dance instruction. After the intervention, the Walk, Walk+ and SSS groups showed gains in cardiorespiratory fitness (CRF), with larger effects in both walking groups compared to the SSS and Dance groups. The Walk, Walk+ and SSS groups also improved in executive function (EF) as measured by reasoning, working memory, and task-switching tests. In the Walk, Walk+, and SSS groups that improved in EF, higher baseline modularity was positively related to EF gains, even after controlling for age, in-scanner motion and baseline EF. No relationship between modularity and EF gains was observed in the Dance group, which did not show training-related gains in CRF or EF control. These results are consistent with previous studies demonstrating that individuals with a more modular brain network organization are more responsive to cognitive training. These findings suggest that the predictive power of modularity may be generalizable across interventions aimed to enhance aspects of cognition and that, especially in low-performing individuals, global network properties can capture individual differences in neuroplasticity.
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影响因子：
4.7
作者：
Bherer L;Erickson KI;Liu-Ambrose T
通讯作者：
Liu-Ambrose T
影响因子：
2.9
作者：
Chaddock L;Erickson KI;Prakash RS;Kim JS;Voss MW;Vanpatter M;Pontifex MB;Raine LB;Konkel A;Hillman CH;Cohen NJ;Kramer AF
通讯作者：
Kramer AF
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
16.6
作者：
Chadick, James Z.;Zanto, Theodore P.;Gazzaley, Adam
通讯作者：
Gazzaley, Adam