Effects of Ion-Transporting Proteins on the Digestive System Under Hypoxia.
Effects of Ion-Transporting Proteins on the Digestive System Under Hypoxia.
复制标题
缺氧条件下离子转运蛋白对消化系统的影响
DOI：
10.3389/fphys.2022.870243
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发表时间：
2022
影响因子：
4
通讯作者：
Xie, Rui
中科院分区：
文献类型：
--
作者：
Xiang, Yiwei;Fan, Dongdong;An, Qimin;Zhang, Ting;Wu, Xianli;Ding, Jianhong;Xu, Xiaolin;Yue, Gengyu;Tang, Siqi;Du, Qian;Xu, Jingyu;Xie, Rui
缺氧是一种氧限制状态，主要介导人体内的病理过程，参与正常生理过程的调节。在低氧环境中，人体内稳态的主要调节因子是低氧诱导因子家族(HIF)。缺氧诱导因子可以调节许多低氧诱导基因的表达，从而参与人体的各种生理和病理过程。离子转运蛋白是一类极其重要的蛋白质。离子转运蛋白分布在细胞膜或细胞器上，严格控制细胞或细胞器中离子的流入或流出。细胞内离子的变化往往与人体内广泛的生理和病理过程密切相关。大量研究证实，低氧及其调控因子可以调控离子转运蛋白相关基因的转录和表达。在低氧应激条件下，离子转运蛋白在低氧条件下的调节和相互作用往往会导致多种人体系统疾病甚至肿瘤的发生。以离子转运蛋白和低氧为靶点，探讨消化系统疾病的发病机制和靶向治疗有望成为新的突破口。
Hypoxia refers to a state of oxygen limitation, which mainly mediates pathological processes in the human body and participates in the regulation of normal physiological processes. In the hypoxic environment, the main regulator of human body homeostasis is the hypoxia-inducible factor family (HIF). HIF can regulate the expression of many hypoxia-induced genes and then participate in various physiological and pathological processes of the human body. Ion-transporting proteins are extremely important types of proteins. Ion-transporting proteins are distributed on cell membranes or organelles and strictly control the inflow or outflow of ions in cells or organelles. Changes in ions in cells are often closely related to extensive physiological and pathological processes in the human body. Numerous studies have confirmed that hypoxia and its regulatory factors can regulate the transcription and expression of ion-transporting protein-related genes. Under hypoxic stress, the regulation and interaction of ion-transporting proteins by hypoxia often leads to diseases of various human systems and even tumors. Using ion-transporting proteins and hypoxia as targets to explore the mechanism of digestive system diseases and targeted therapy is expected to become a new breakthrough point.
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影响因子：
5.3
作者：
Chu W;Wan L;Zhao D;Qu X;Cai F;Huo R;Wang N;Zhu J;Zhang C;Zheng F;Cai R;Dong D;Lu Y;Yang B
通讯作者：
Yang B
影响因子：
8.4
作者：
Ferro, Ana;Peleteiro, Barbara;Lunet, Nuno
通讯作者：
Lunet, Nuno
缺氧预处理可保护CA（2+） - 肠粘膜细胞的ATPase激活在大鼠肝移植模型中免受R/I损伤。
影响因子：
4.3
作者：
Ji ZP;Li YX;Shi BX;Zhuang ZN;Yang JY;Guo S;Xu XZ;Xu KS;Li HL
通讯作者：
Li HL
影响因子：
3.5
作者：
Fuentes IM;Christianson JA
通讯作者：
Christianson JA
影响因子：
4
作者：
Chen, Min;Huang, Shu-Ling;Zhang, Xiao-Qi;Zhang, Bin;Zhu, Hao;Yang, Vincent W.;Zou, Xiao-Ping
通讯作者：
Zou, Xiao-Ping