Heterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayers.
Heterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayers.
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磷脂单层的非晶二氧化硅纳米颗粒吸附的异质速率常数。
DOI：
10.1021/acs.langmuir.1c03155
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发表时间：
2022-05-10
期刊：
影响因子：
3.9
通讯作者：
Nelson, Andrew L.
中科院分区：
文献类型：
--
作者：
Vakurov, Alex;Drummond-Brydson, Rik;William, Nicola;Sanver, Didem;Bastus, Neus;Moriones, Oscar H.;Puntes, V.;Nelson, Andrew L.
近年来，无定形二氧化硅纳米颗粒与磷脂单层和双层的相互作用受到了极大的关注，并且对于评估此类物质的潜在细胞毒性具有重要意义，无论是天然的还是出于纳米医学药物递送和其他应用的目的合成的。本通讯研究二氧化硅纳米粒子吸附到磷脂单层的速率，以提取一个异质速率常数的数据。该速率常数与分散体中单位浓度的单层表面单位面积上SiO2纳米颗粒吸附层的初始生长速率有关。实验采用二油酰磷脂酰胆碱（DOPC）单分子膜沉积在Pt/Hg电极上的流动池进行。对可溶性二氧化硅与这些层的相互作用进行了额外的研究。结果表明，速率常数相对于二氧化硅纳米颗粒尺寸是有效恒定的。这被解释为表明水合SiO2分子物质与磷脂极性基团的相互作用是分子引发事件（MIE），定义为二氧化硅颗粒表面与磷脂层表面的初始相互作用，促进二氧化硅纳米颗粒在DOPC上的吸附。该结论与所观察到的可溶性SiO2与DOPC层的显著相互作用以及二氧化硅-水界面的既定性质一致。
The interaction of amorphous silica nanoparticles with phospholipid monolayers and bilayers has received a great deal of interest in recent years and is of importance for assessing potential cellular toxicity of such species, whether natural or synthesized for the purpose of nanomedical drug delivery and other applications. This present communication studies the rate of silica nanoparticle adsorption on to phospholipid monolayers in order to extract a heterogeneous rate constant from the data. This rate constant relates to the initial rate of growth of an adsorbed layer of nanoparticles as SiO2 on a unit area of the monolayer surface from unit concentration in dispersion. Experiments were carried out using the system of dioleoyl phosphatidylcholine (DOPC) monolayers deposited on Pt/Hg electrodes in a flow cell. Additional studies were carried out on the interaction of soluble silica with these layers. Results show that the rate constant is effectively constant with respect to silica nanoparticle size. This is interpreted as indicating that the interaction of hydrated SiO2 molecular species with phospholipid polar groups is the molecular initiating event (MIE) defined as the initial interaction of the silica particle surface with the phospholipid layer surface promoting the adsorption of silica nanoparticles on DOPC. The conclusion is consistent with the observed significant interaction of soluble SiO2 with the DOPC layer and the established properties of the silica–water interface.
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影响因子：
6.6
作者：
Coldrick, Zachary;Steenson, Paul;Nelson, Andrew
通讯作者：
Nelson, Andrew
DOI：
10.1073/pnas.0803798105
发表时间：
2008-07-22
影响因子：
11.1
作者：
Dove, Patricia M.;Han, Nizhou;De Yoreo, James J.
通讯作者：
De Yoreo, James J.
DOI：
10.1016/j.nano.2015.03.004
发表时间：
2015-08-01
影响因子：
5.4
作者：
Kim, In-Yong;Joachim, Elizabeth;Kim Kevin, Kyekyoon
通讯作者：
Kim Kevin, Kyekyoon
影响因子：
--
作者：
ALEXANDER, GB;HESTON, WM;ILER, RK
通讯作者：
ILER, RK
影响因子：
3.3
作者：
Dalstein, Laetitia;Potapova, Elizaveta;Tyrode, Eric
通讯作者：
Tyrode, Eric