Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance.
Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance.
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DOI：
10.1002/jmri.24150
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发表时间：
2014-02
影响因子：
4.4
通讯作者：
Ally, Brandon A.
中科院分区：
文献类型：
--
作者：
Donahue, Manus J.;Hussey, Erin;Rane, Swati;Wilson, Tracy;van Osch, Matthias;Hartkamp, Nolan;Hendrikse, Jeroen;Ally, Brandon A.
关键词：
To evaluate how flow-territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain’s ability to respond to age-related changes in brain function. These patterns have been investigated in cerebrovascular disease, however here we evaluated how flow-territory asymmetry related to memory generally in older adults. A multi-faceted MRI protocol, including vessel-encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD-Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n=15; age=64.5±7 yrs) and age-matched mild cognitive impairment volunteers (MCI; n=7; age=62.7±3.7 yrs). An inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (P=0.04), which reversed in MCI volunteers (P=0.04). No relationship was found between memory performance and cortical tissue volume in either group (P>0.05). Group-level differences for HC volunteers performing above vs. below average on CERAD-I were observed for flow-territory asymmetry (P<0.02) and cortical volume (P<0.05) only. Findings suggest that flow-territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
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作者：
MacIntosh, Bradley J.;Filippini, Nicola;Jezzard, Peter
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Jezzard, Peter
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158.5
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in 't Veld, BA;Ruitenberg, A;Stricker, BHC
通讯作者：
Stricker, BHC
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Hendrikse, J;van der Grond, J;Golay, X
通讯作者：
Golay, X
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8.3
作者：
Liebeskind, DS
通讯作者：
Liebeskind, DS