Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management.
Oral Candidosis: Pathophysiology and Best Practice for Diagnosis, Classification, and Successful Management.
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DOI：
10.3390/jof7070555
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发表时间：
2021-07-13
期刊：
影响因子：
--
通讯作者：
Lu SY
中科院分区：
文献类型：
--
作者：
Lu SY
口腔念珠菌病是最常见的真菌感染，经常发生在因其他疾病或病症而虚弱的患者中。没有任何念珠菌病是无缘无故发生的；因此，口腔念珠菌病被认为是一种患病者的疾病。先前的研究已将口腔念珠菌病确定为全身性疾病的标志，例如血虚症、糖尿病、白细胞减少症、艾滋病毒/艾滋病、恶性肿瘤以及富含碳水化合物的饮食、药物或免疫抑制疾病。念珠菌与宿主之间的一系列相互作用是动态且复杂的。念珠菌表现出生长、增殖、逃避宿主防御和在宿主内存活以诱导真菌感染的多方面策略。口腔念珠菌病有多种临床形式，包括假膜念珠菌病、红斑念珠菌病、口角炎、正中菱形舌炎、唇念珠菌病、超百万念珠菌病、皮肤粘膜念珠菌病、增生性念珠菌病、口咽念珠菌病和罕见的化脓性念珠菌病。预后通常良好，但由于诊断不正确、遗漏其他病理、无法解决潜在的危险因素或抗真菌药物处方不准确，治疗失败或复发也很常见。在免疫功能低下的患者中，口咽念珠菌病可以扩散到血液或上胃肠道，导致潜在致命的全身性念珠菌病。因此，本综述描述了口腔念珠菌病的病理生理学和诊断、实用分类和成功治疗的最佳实践。
Oral candidosis is the most common fungal infection that frequently occurs in patients debilitated by other diseases or conditions. No candidosis happens without a cause; hence oral candidosis has been branded as a disease of the diseased. Prior research has identified oral candidosis as a mark of systemic diseases, such as hematinic deficiency, diabetes mellitus, leukopenia, HIV/AIDS, malignancies, and carbohydrate-rich diet, drugs, or immunosuppressive conditions. An array of interaction between Candida and the host is dynamic and complex. Candida exhibits multifaceted strategies for growth, proliferation, evasion of host defenses, and survival within the host to induce fungal infection. Oral candidosis presents a variety of clinical forms, including pseudomembranous candidosis, erythematous candidosis, angular cheilitis, median rhomboid glossitis, cheilocandidosis, juxtavermillion candidosis, mucocutaneous candidosis, hyperplastic candidosis, oropharyngeal candidosis, and rare suppurative candidosis. The prognosis is usually favorable, but treatment failure or recurrence is common due to either incorrect diagnosis, missing other pathology, inability to address underlying risk factors, or inaccurate prescription of antifungal agents. In immunocompromised patients, oropharyngeal candidosis can spread to the bloodstream or upper gastrointestinal tract, leading to potentially lethal systemic candidosis. This review therefore describes oral candidosis with regard to its pathophysiology and best practice for diagnosis, practical classification, and successful management.
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DOI：
10.14219/jada.archive.1988.0327
发表时间：
1988-02-01
影响因子：
3.9
作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
Revista mexicana de fitopatología
影响因子：
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