Coevolving MAPK and PID phosphosites indicate an ancient environmental control of PIN auxin transporters in land plants.
Coevolving MAPK and PID phosphosites indicate an ancient environmental control of PIN auxin transporters in land plants.
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DOI：
10.1002/1873-3468.12929
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发表时间：
2018-01
期刊：
影响因子：
3.5
通讯作者：
Dóczi R
中科院分区：
文献类型：
--
作者：
Dory M;Hatzimasoura E;Kállai BM;Nagy SK;Jäger K;Darula Z;Nádai TV;Mészáros T;López-Juez E;Barnabás B;Palme K;Bögre L;Ditengou FA;Dóczi R
植物生长灵活地适应环境条件，这意味着环境信号和发育调节之间的串扰。在这里，我们发现PIN生长素外排载体家族具有三个高度保守的推定的促分裂原活化蛋白激酶（MAPK）位点，其邻近充分表征的AGC激酶PINs的磷酸化位点，其调节PIN的极性定位和定向生长素运输，从而支持器官生长。PIN1的保守位点在体外被两种环境激活的MAPK MPK4和MPK6磷酸化。与AGC激酶相反，MAPK介导的PIN1在邻近位点的磷酸化导致PIN1质膜定位的部分丧失。MAPK介导的PIN运输调节可能参与植物生长的环境调节。
Plant growth flexibly adapts to environmental conditions, implying cross‐talk between environmental signalling and developmental regulation. Here, we show that the PIN auxin efflux carrier family possesses three highly conserved putative mitogen‐activated protein kinase (MAPK) sites adjacent to the phosphorylation sites of the well‐characterised AGC kinase PINOID, which regulates the polar localisation of PINs and directional auxin transport, thereby underpinning organ growth. The conserved sites of PIN1 are phosphorylated in vitro by two environmentally activated MAPKs, MPK4 and MPK6. In contrast to AGC kinases, MAPK‐mediated phosphorylation of PIN1 at adjacent sites leads to a partial loss of the plasma membrane localisation of PIN1. MAPK‐mediated modulation of PIN trafficking may participate in environmental adjustment of plant growth.
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影响因子：
64.8
作者：
Blilou, I;Xu, J;Scheres, B
通讯作者：
Scheres, B
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