Defining Cognitive Reserve and Implications for Cognitive Aging.
Defining Cognitive Reserve and Implications for Cognitive Aging.
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DOI：
10.1007/s11910-019-0917-z
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发表时间：
2019-01-09
影响因子：
5.6
通讯作者：
Soldan A
中科院分区：
文献类型：
--
作者：
Pettigrew C;Soldan A
本综述的目的是总结认知储备（CR）的当前概念模型和相关概念，并在衰老和阿尔茨海默病的背景下讨论这些概念的证据。迄今为止的证据支持这一观点，即通过反映一生经历的代理变量测量的较高水平的CR与更好的认知表现相关，并且与事件轻度认知障碍/痴呆的风险降低相关。然而，CR对纵向认知轨迹的影响尚不清楚，可能受到许多因素的影响。虽然有一些有希望的证据表明，CR的一些代理措施可能会影响大脑结构的措施，需要更多的研究。CR的保护作用可能为随着年龄的增长保持认知功能和认知健康提供了一种重要的机制，部分原因是它可以在整个生命周期中得到增强。然而，需要更多的研究CR的保护机制。
The aim of this review is to summarize current conceptual models of cognitive reserve (CR) and related concepts and to discuss evidence for these concepts within the context of aging and Alzheimer’s disease. Evidence to date supports the notion that higher levels of CR, as measured by proxy variables reflective of lifetime experiences, are associated with better cognitive performance, and with a reduced risk of incident mild cognitive impairment/dementia. However, the impact of CR on longitudinal cognitive trajectories is unclear and may be influenced by a number of factors. Although there is promising evidence that some proxy measures of CR may influence structural brain measures, more research is needed. The protective effects of CR may provide an important mechanism for preserving cognitive function and cognitive well-being with age, in part because it can be enhanced throughout the lifespan. However, more research on the mechanisms by which CR is protective is needed.
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影响因子：
2.6
作者：
Cizginer S;Marcantonio E;Vasunilashorn S;Pascual-Leone A;Shafi M;Schmitt EM;Inouye SK;Jones RN
通讯作者：
Jones RN
影响因子：
11.2
作者：
Boyle PA;Yu L;Wilson RS;Leurgans SE;Schneider JA;Bennett DA
通讯作者：
Bennett DA
影响因子：
4.2
作者：
Chan, Dennis;Shafto, Meredith;Henson, Rik N.
通讯作者：
Henson, Rik N.
影响因子：
14
作者：
通讯作者：
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影响因子：
5.7
作者：
Cadar D;Robitaille A;Clouston S;Hofer SM;Piccinin AM;Muniz-Terrera G
通讯作者：
Muniz-Terrera G