The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study.
The Cognitive Reserve Model in the Development of Delirium: The Successful Aging After Elective Surgery Study.
复制标题
DOI：
10.1177/0891988717732152
复制
发表时间：
2017-11
影响因子：
2.6
通讯作者：
Jones RN
中科院分区：
文献类型：
--
作者：
Cizginer S;Marcantonio E;Vasunilashorn S;Pascual-Leone A;Shafi M;Schmitt EM;Inouye SK;Jones RN
我们评估了认知和脑储备标记物在改变与病理生理标记物相关的术后谵妄风险中的作用。择期手术后成功老化（SAGES）研究入组了556例年龄≥ 70岁、无痴呆且计划接受大手术的成人。在术前和住院期间每天评估患者的谵妄。我们使用C-反应蛋白（CRP）作为炎症的病理生理标志物，以前与谵妄有关。储备的标志物包括词汇知识，教育，认知活动，职业类型和复杂性，头围，颅内容量和休闲活动。词汇知识、认知活动和教育显著改变了CRP与术后谵妄的相关性（p <0.01）。然而，效应量-当具有统计学显著性时-在量级上很小。观察到词汇知识的最强效应修正：高分通常具有保护作用，但在高水平CRP时则不然。选择储备标志物降低与较低级别炎症过程相关的谵妄风险，支持储备在谵妄中的作用。
We evaluated the role of cognitive and brain reserve markers in modifying risk for postoperative delirium associated with a pathophysiologic marker. The Successful Aging after Elective Surgery (SAGES) study enrolled 556 adults age ≥ 70 years without dementia scheduled for major surgery. Patients were assessed preoperatively and daily during hospitalization for delirium. We used C-reactive protein (CRP) as a pathophysiologic marker of inflammation, previously associated with delirium. Markers of reserve included vocabulary knowledge, education, cognitive activities, occupation type and complexity, head circumference, intracranial volume, and leisure activities. Vocabulary knowledge, cognitive activities, and education significantly modified the association of CRP and postoperative delirium (p < .01). However, effect sizes -- when statistically significant -- were small in magnitude. The strongest effect modification was observed for vocabulary knowledge: high scores were generally protective, but not at high levels of CRP. Select reserve markers attenuate the risk of delirium associated with lower grade inflammatory processes, supporting the role of reserve in delirium.
登录
查看更多内容
影响因子：
168.9
作者：
Inouye, Sharon K.;Westendorp, Rudi G. J.;Saczynski, Jane S.
通讯作者：
Saczynski, Jane S.
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
影响因子：
9.1
作者：
CAIN, PS;TREIMAN, DJ
通讯作者：
TREIMAN, DJ
DOI：
10.1111/j.1532-5415.2005.53120.x
发表时间：
2005-02-01
影响因子：
6.3
作者：
Inouye, SK;Leo-Summers, L;Agostini, JV
通讯作者：
Agostini, JV
DOI：
10.1017/s1355617710001748
发表时间：
2011-07
影响因子：
2.6
作者：
Jones, Richard N.;Manly, Jennifer;Glymour, M. Maria;Rentz, Dorene M.;Jefferson, Angela L.;Stern, Yaakov
通讯作者：
Stern, Yaakov