Alternative Splicing of Pre-mRNA in the Control of Immune Activity.
Alternative Splicing of Pre-mRNA in the Control of Immune Activity.
复制标题
前体 mRNA 的选择性剪接在免疫活性控制中的作用
DOI：
10.3390/genes12040574
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发表时间：
2021-04-15
期刊：
影响因子：
3.5
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Su Z;Huang D
人类免疫应答是一个复杂的过程，其在预防微生物感染中对许多外源性抗原作出应答，以及在监视肿瘤和自身免疫性疾病中对内源性组分作出应答，并且需要大量分子来携带免疫活性的功能复杂性。前mRNA的选择性剪接通过产生不同的转录亚型来补充与免疫反应相关的有限基因的功能，在免疫细胞发育和免疫活性调节中发挥着重要作用。此外，多种因子已被鉴定为在顺式、反式或共转录水平上参与控制可变剪接，并且RNA的异常剪接导致感染、免疫疾病和肿瘤中免疫活性的异常调节。本文综述了近年来免疫相关可变剪接变异体的产生、临床疾病和可能的调控机制等方面的研究进展。我们还讨论了选择性剪接产生的新抗原的免疫反应，最后，我们提出了一些选择性剪接和免疫相关的问题，根据我们的知识。
The human immune response is a complex process that responds to numerous exogenous antigens in preventing infection by microorganisms, as well as to endogenous components in the surveillance of tumors and autoimmune diseases, and a great number of molecules are necessary to carry the functional complexity of immune activity. Alternative splicing of pre-mRNA plays an important role in immune cell development and regulation of immune activity through yielding diverse transcriptional isoforms to supplement the function of limited genes associated with the immune reaction. In addition, multiple factors have been identified as being involved in the control of alternative splicing at the cis, trans, or co-transcriptional level, and the aberrant splicing of RNA leads to the abnormal modulation of immune activity in infections, immune diseases, and tumors. In this review, we summarize the recent discoveries on the generation of immune-associated alternative splice variants, clinical disorders, and possible regulatory mechanisms. We also discuss the immune responses to the neoantigens produced by alternative splicing, and finally, we issue some alternative splicing and immunity correlated questions based on our knowledge.
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DOI：
10.4049/jimmunol.0804224
发表时间：
2009-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Korbel DS;Norman PJ;Newman KC;Horowitz A;Gendzekhadze K;Parham P;Riley EM
通讯作者：
Riley EM
影响因子：
30.5
作者：
Chang VT;Fernandes RA;Ganzinger KA;Lee SF;Siebold C;McColl J;Jönsson P;Palayret M;Harlos K;Coles CH;Jones EY;Lui Y;Huang E;Gilbert RJC;Klenerman D;Aricescu AR;Davis SJ
通讯作者：
Davis SJ
影响因子：
14.9
作者：
Davis-Turak J;Johnson TL;Hoffmann A
通讯作者：
Hoffmann A
DOI：
10.1038/nrm.2017.27
发表时间：
2017-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Baralle FE;Giudice J
通讯作者：
Giudice J
影响因子：
20.3
作者：
Cordoba, Shaun-Paul;Choudhuri, Kaushik;van der Merwe, P. Anton
通讯作者：
van der Merwe, P. Anton