Staphylococcus xylosus and Staphylococcus aureus as commensals and pathogens on murine skin.
Staphylococcus xylosus and Staphylococcus aureus as commensals and pathogens on murine skin.
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DOI：
10.1186/s42826-023-00169-0
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发表时间：
2023-08-02
影响因子：
2.9
通讯作者：
Garrett-Sinha, Lee Ann
中科院分区：
文献类型：
--
作者：
Battaglia, Michael;Garrett-Sinha, Lee Ann
皮肤溃疡、皮肤皮炎和皮肤感染是实验室小鼠群体中的常见现象，在某些免疫功能低下的菌株中经常发现患病率增加。虽然在许多情况下，这些皮肤状况是轻微的，但在其他情况下，它们可能是严重的，并导致动物发病。此外，皮肤感染和溃疡的存在可能使实验方案的解释复杂化，包括那些检查免疫细胞激活的实验方案。葡萄球菌属细菌是小鼠皮肤损伤中最常见的病原体。特别是，金黄色葡萄球菌和木质葡萄球菌都被认为是小鼠皮肤上的病原体。金黄色葡萄球菌是一种众所周知的人类皮肤病原体，但木糖葡萄球菌在人类皮肤感染方面尚未见报道，这表明木糖葡萄球菌作为皮肤病原体的能力存在物种特异性差异。本文综述了金黄色葡萄球菌和木糖葡萄球菌与小鼠皮肤感染有关的研究，并描述了它们对组织的粘附性和毒性的相关因素。我们讨论了小鼠和人类皮肤的潜在差异，这可能是木葡萄球菌在小鼠皮肤而不是人类皮肤上作为病原体的能力的基础。最后，我们还描述了小鼠突变体对葡萄球菌皮肤感染的易感性增加。这些突变体指出了在共生葡萄球菌细菌控制中重要的途径。这里的信息可能对研究容易被葡萄球菌感染的小鼠菌株的研究人员有用。
Skin ulcers, skin dermatitis and skin infections are common phenomena in colonies of laboratory mice and are often found at increased prevalence in certain immunocompromised strains. While in many cases these skin conditions are mild, in other cases they can be severe and lead to animal morbidity. Furthermore, the presence of skin infections and ulcerations can complicate the interpretation of experimental protocols, including those examining immune cell activation. Bacterial species in the genus Staphylococcus are the most common pathogens recovered from skin lesions in mice. In particular, Staphylococcus aureus and Staphylococcus xylosus have both been implicated as pathogens on murine skin. Staphylococcus aureus is a well-known pathogen of human skin, but S. xylosus skin infections in humans have not been described, indicating that there is a species-specific difference in the ability of S. xylosus to serve as a skin pathogen. The aim of this review is to summarize studies that link S. aureus and S. xylosus to skin infections of mice and to describe factors involved in their adherence to tissue and their virulence. We discuss potential differences in mouse and human skin that might underlie the ability of S. xylosus to act as a pathogen on murine skin, but not human skin. Finally, we also describe mouse mutants that have shown increased susceptibility to skin infections with staphylococcal bacteria. These mutants point to pathways that are important in the control of commensal staphylococcal bacteria. The information here may be useful to researchers who are working with mouse strains that are prone to skin infections with staphylococcal bacteria.
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影响因子：
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通讯作者：
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