Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species.
Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species.
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两种高度多食性和入侵性 Helicoverpa 害虫物种进化和分化背后的基因组创新、转录可塑性和基因丢失
DOI：
10.1186/s12915-017-0402-6
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发表时间：
2017-07-31
期刊：
影响因子：
5.4
通讯作者：
Wu YD
中科院分区：
文献类型：
--
作者：
Pearce SL;Clarke DF;East PD;Elfekih S;Gordon KHJ;Jermiin LS;McGaughran A;Oakeshott JG;Papanicolaou A;Perera OP;Rane RV;Richards S;Tay WT;Walsh TK;Anderson A;Anderson CJ;Asgari S;Board PG;Bretschneider A;Campbell PM;Chertemps T;Christeller JT;Coppin CW;Downes SJ;Duan G;Farnsworth CA;Good RT;Han LB;Han YC;Hatje K;Horne I;Huang YP;Hughes DST;Jacquin-Joly E;James W;Jhangiani S;Kollmar M;Kuwar SS;Li S;Liu NY;Maibeche MT;Miller JR;Montagne N;Perry T;Qu J;Song SV;Sutton GG;Vogel H;Walenz BP;Xu W;Zhang HJ;Zou Z;Batterham P;Edwards OR;Feyereisen R;Gibbs RA;Heckel DG;McGrath A;Robin C;Scherer SE;Worley KC;Wu YD
背景：棉铃虫和玉米蛾分别是新旧世界农业的主要害虫。两者都是极度多食性的，尤其是棉铃虫，而且棉铃虫已经对许多杀虫剂产生了抗药性。结果：与寄主范围较窄的鳞翅目昆虫相比，棉铃虫/玉米家系在分化约1.5Mya之前，积累了多达100多个特定解毒消化基因家族的成员和100多个额外的味觉受体基因。这两个基因组在基因含量和序列上仍然非常相似，但棉铃虫总体上更加多态，并且H.Zea已经丢失了几个解毒基因，以及大约50个味觉受体基因。它也缺乏在棉铃虫中发现的某些与杀虫剂抗性有关的基因和等位基因。上述扩展的基因家族中的非同义位点正在迅速分化，在这两个物种中，无论是在同源基因之间还是在直系同源基因之间。棉铃虫幼虫全基因组转录组分析表明，棉铃虫幼虫对不同寄主植物的反应差异很大，其中包括许多重复的解毒和消化基因的反应。结论：两种棉铃虫幼虫的极端多噬与参与寄主发现和利用的基因的广泛扩增和新功能有关，以及在不同寄主上的通用转录反应。棉铃虫近年来入侵美洲意味着，杂交可以产生既适应当地又具有抗药性的种群。
Background:Helicoverpa armigera and Helicoverpa zea are major caterpillar pests of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely polyphagous, and H. armigera has developed resistance to many insecticides. Here we use comparative genomics, transcriptomics and resequencing to elucidate the genetic basis for their properties as pests.Results:We find that, prior to their divergence about 1.5 Mya, the H. armigera/H. zea lineage had accumulated up to more than 100 more members of specific detoxification and digestion gene families and more than 100 extra gustatory receptor genes, compared to other lepidopterans with narrower host ranges. The two genomes remain very similar in gene content and order, but H. armigera is more polymorphic overall, and H. zea has lost several detoxification genes, as well as about 50 gustatory receptor genes. It also lacks certain genes and alleles conferring insecticide resistance found in H. armigera. Non-synonymous sites in the expanded gene families above are rapidly diverging, both between paralogues and between orthologues in the two species. Whole genome transcriptomic analyses of H. armigera larvae show widely divergent responses to different host plants, including responses among many of the duplicated detoxification and digestion genes.Conclusions:The extreme polyphagy of the two heliothines is associated with extensive amplification and neofunctionalisation of genes involved in host finding and use, coupled with versatile transcriptional responses on different hosts. H. armigera's invasion of the Americas in recent years means that hybridisation could generate populations that are both locally adapted and insecticide resistant.
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影响因子：
10.7
作者：
Minh BQ;Nguyen MA;von Haeseler A
通讯作者：
von Haeseler A
影响因子：
1.4
作者：
Allinghi, Armando;Calcagno, Graciela;Vilardi, Juan Cesar
通讯作者：
Vilardi, Juan Cesar
影响因子：
2.1
作者：
Berger, D.;Walters, R. J.;Blanckenhorn, W. U.
通讯作者：
Blanckenhorn, W. U.
Helicoverpa Armigera（Lepidoptera：Noctuidae）及其与H. Zea的关系的线粒体DNA分析。
影响因子：
3.4
作者：
Behere GT;Tay WT;Russell DA;Heckel DG;Appleton BR;Kranthi KR;Batterham P
通讯作者：
Batterham P
影响因子：
3.8
作者：
Cheesman, Matthew J.;Traylor, Matthew. J.;Oakeshott, John G.
通讯作者：
Oakeshott, John G.