Clinical and Serological Findings of Madariaga and Venezuelan Equine Encephalitis Viral Infections: A Follow-up Study 5 Years After an Outbreak in Panama.
Clinical and Serological Findings of Madariaga and Venezuelan Equine Encephalitis Viral Infections: A Follow-up Study 5 Years After an Outbreak in Panama.
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DOI：
10.1093/ofid/ofaa359
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发表时间：
2020-09
影响因子：
4.2
通讯作者：
Vittor AY
中科院分区：
文献类型：
--
作者：
Carrera JP;Pittí Y;Molares-Martínez JC;Casal E;Pereyra-Elias R;Saenz L;Guerrero I;Galué J;Rodriguez-Alvarez F;Jackman C;Pascale JM;Armien B;Weaver SC;Donnelly CA;Vittor AY
Madariaga病毒（MADV）感染的人类病例于2010年在巴拿马东部爆发期间首次发现，委内瑞拉马脑炎病毒（VEEV）也在那里传播。人们对甲病毒感染的长期后果知之甚少。2015年对2010年疫情进行了后续研究。另一项调查是在2017年巴拿马东部邻近人群爆发甲病毒后两周进行的。在这两个人群中进行了血清学研究和统计分析。在最初甲病毒血清阴性的参与者中（n = 35/65），5年内观察到MADV的血清转化率为14.3%（95% CI，4.8%-30.3%），VEEV为8.6%（95% CI，1.8%-23.1%）。在最初MADV血清阳性的参与者中（n = 14/65），VEEV血清转换发生在35.7%（95%CI，12.8%-64.9%）。在VEEV血清阳性的参与者中（n = 16/65），MADV血清转换发生率为6.3%（95%CI，0.2%-30.2%）。在2010年最初血清阳性的患者中，有14.3%（95%CI，1.8%-42.8%）观察到MADV血清逆转。基线MADV血清阳性参与者中的VEEV血清转换显著高于甲病毒阴性参与者。在2017年抽样人群中，MADV和VEEV血清阳性率分别为13.2%和16.8%。甲病毒血清阳性参与者中记忆力丧失、失眠、烦躁和癫痫发作的频率明显高于血清阴性参与者。5年来MADV和VEEV的高血清转化率表明这两种病毒在巴拿马经常传播。MADV感染可增强对VEEV感染的易感性。我们提供了MADV和VEEV暴露后持续神经系统症状长达5年的证据。
Human cases of Madariaga virus (MADV) infection were first detected during an outbreak in 2010 in eastern Panama, where Venezuelan equine encephalitis virus (VEEV) also circulates. Little is known about the long-term consequences of either alphavirus infection. A follow-up study of the 2010 outbreak was undertaken in 2015. An additional survey was carried out 2 weeks after a separate 2017 alphavirus outbreak in a neighboring population in eastern Panama. Serological studies and statistical analyses were undertaken in both populations. Among the originally alphavirus-seronegative participants (n = 35 of 65), seroconversion was observed at a rate of 14.3% (95% CI, 4.8%–30.3%) for MADV and 8.6% (95% CI, 1.8%–23.1%) for VEEV over 5 years. Among the originally MADV-seropositive participants (n = 14 of 65), VEEV seroconversion occurred in 35.7% (95% CI, 12.8%–64.9%). In the VEEV-seropositive participants (n = 16 of 65), MADV seroconversion occurred in 6.3% (95% CI, 0.2%–30.2%). MADV seroreversion was observed in 14.3% (95% CI, 1.8%–42.8%) of those who were originally seropositive in 2010. VEEV seroconversion in the baseline MADV-seropositive participants was significantly higher than in alphavirus-negative participants. In the population sampled in 2017, MADV and VEEV seroprevalence was 13.2% and 16.8%, respectively. Memory loss, insomnia, irritability, and seizures were reported significantly more frequently in alphavirus-seropositive participants than in seronegative participants. High rates of seroconversion to MADV and VEEV over 5 years suggest frequent circulation of both viruses in Panama. Enhanced susceptibility to VEEV infection may be conferred by MADV infection. We provide evidence of persistent neurologic symptoms up to 5 years following MADV and VEEV exposure.
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影响因子：
--
作者：
Johnson, B. W.;Kosoy, O.;Weaver, S. C.
通讯作者：
Weaver, S. C.
影响因子：
5.5
作者：
Pittman, Phillip R.;Liu, Ching-Tong;Gibbs, Paul H.
通讯作者：
Gibbs, Paul H.
影响因子：
158.5
作者：
Carrera, Jean-Paul;Forrester, Naomi;Weaver, Scott C.
通讯作者：
Weaver, Scott C.
DOI：
10.1128/aem.26.4.485-488.1973
发表时间：
1973-01-01
期刊：
APPLIED MICROBIOLOGY
影响因子：
--
作者：
CALISHER, CH;SASSO, DR;SATHER, GE
通讯作者：
SATHER, GE
影响因子：
7.7
作者：
LEON, CA;JARAMILLO, R;DEGUZMAN, R
通讯作者：
DEGUZMAN, R