Causal inference considerations for endocrine disruptor research in children's health.
Causal inference considerations for endocrine disruptor research in children's health.
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DOI：
10.1146/annurev-publhealth-031811-124556
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发表时间：
2013
影响因子：
20.8
通讯作者：
Wolff MS
中科院分区：
文献类型：
--
作者：
Engel SM;Wolff MS
大量人群暴露于内分泌干扰化学品，加上现有的生物标志物和公众的关注，导致了人类健康影响研究的爆炸式增长。与此同时，关于含有内分泌干扰物（ED）的某些消费品成分的法规发生了显著变化。然而，重要的问题仍然是证据的权重ED与人类健康终点。在这篇综述中，我们批判性地研究了将艾德暴露与儿童神经发育联系起来的文献，特别关注两种模型暴露，以证明与生物累积相关的问题[例如，多氯联苯（PCBs）]和快速代谢（例如，邻苯二甲酸酯）化合物。研究设计，混杂和暴露测量的问题被认为是。鉴于这些化合物的广泛接触，即使对人类健康的影响很小，也可能对公共卫生产生重大影响。因此，要想进一步理解任何影响，都需要认真关注因果推理的原则。
Substantial population exposure to endocrine disrupting chemicals, combined with available biomarkers and public concern, has resulted in an explosion of human health effects research. At the same time, remarkable shifts in the regulations governing the composition of some consumer products that contain endocrine disruptors (EDs) has occurred. However, important questions remain as to the weight of evidence linking EDs to human health end points. In this review, we critically examine the literature linking ED exposures to child neurodevelopment, focusing in particular on two model exposures to demonstrate issues related to bioaccumulative [e.g., polychlorinated biphenyls (PCBs)] and rapidly metabolized (e.g., phthalates) compounds, respectively. Issues of study design, confounding, and exposure measurement are considered. Given widespread exposure to these compounds, the potential public health consequences of even small effects on human health are substantial. Therefore, advancing our understanding of any impact calls for careful attention to the principles of causal inference.
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影响因子：
10.4
作者：
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发表时间：
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期刊：
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影响因子：
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作者：
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