Inter-individual variability in current direction for common tDCS montages.
Inter-individual variability in current direction for common tDCS montages.
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常见tDCS导联组合电流方向的个体间变异性。
DOI：
10.1016/j.neuroimage.2022.119501
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发表时间：
2022-10-15
期刊：
影响因子：
5.7
通讯作者：
Bestmann, Sven
中科院分区：
文献类型：
--
作者：
Evans, Carys;Zich, Catharina;Lee, Jenny S. A.;Ward, Nick;Bestmann, Sven
关键词：
径向向内电流可以被递送到M1的不同子区域。靶向银行与冠可能通过不同的机制调节兴奋性。电流方向的个体间变异性较大，发生在导联组合中。电极位置有助于近似电流方向通过中央前回。对电流方向的个体化控制可以最大限度地减少变异性。相对于皮质表面的施加电流的方向是经颅直流电刺激（tDCS）效果的关键决定因素。解剖结构中的个体间差异影响皮质靶处电流方向的一致性。然而，这种变化的程度仍未确定。使用电流模型（CFM），我们量化了tDCS电流方向在皮质靶（左初级运动皮质，M1）的个体间变异性。比较了使用圆形电极靶向M1的三种导联组合：PA-tDCS定向电流在相对于M1的后-前方向上垂直于中央沟，ML-tDCS定向电流在内侧-外侧方向上平行于中央沟，以及在M1和对侧前额上应用传统tDCS电极。在来自人类连接组项目的50个健康大脑扫描中，我们提取了脑沟库（M1 BANK）和脑回冠（M1 CROWN）以及相邻的初级体感皮层（S1 BANK和S1 CROWN）中灰质表面的电流方向和强度。结果证实了所有导联组合中电流方向的显著个体间变异性（50%-150%）。由PA-tDCS产生的径向内向电流主要位于M1 BANK，而对于常规tDCS，它聚集在M1 CROWN。径向内向电流在功能不同的M1亚区的差异提出了可检验的假设，即PA-tDCS和常规tDCS通过不同的机制调节皮质兴奋性。我们表明，电极位置可以用来密切近似电流方向在M1和中央前回，提供了一个基于里程碑的方法tDCS应用程序来解决的假设，而不需要MRI。相比之下，ML-tDCS电流更切向取向，这与较弱的体细胞极化有关。电流方向的显著个体间变异性可能导致这些方案报告的可变神经调节效应，强调需要个性化电极导联，包括电流方向的控制。
Radial inward current can be delivered to different subregions of M1. Targeting bank versus crown may modulate excitability through different mechanisms. Large inter-individual variability in current direction occurs across montages. Electrode locations help approximate current direction across the precentral gyrus. Individualised control of current direction could minimise variability. The direction of applied electric current relative to the cortical surface is a key determinant of transcranial direct current stimulation (tDCS) effects. Inter-individual differences in anatomy affect the consistency of current direction at a cortical target. However, the degree of this variability remains undetermined. Using current flow modelling (CFM), we quantified the inter-individual variability in tDCS current direction at a cortical target (left primary motor cortex, M1). Three montages targeting M1 using circular electrodes were compared: PA-tDCS directed current perpendicular to the central sulcus in a posterior-anterior direction relative to M1, ML-tDCS directed current parallel to the central sulcus in a medio-lateral direction, and conventional-tDCS applied electrodes over M1 and the contralateral forehead. In 50 healthy brain scans from the Human Connectome Project, we extracted current direction and intensity from the grey matter surface in the sulcal bank (M1BANK) and gyral crown (M1CROWN), and neighbouring primary somatosensory cortex (S1BANK and S1CROWN). Results confirmed substantial inter-individual variability in current direction (50%–150%) across all montages. Radial inward current produced by PA-tDCS was predominantly located in M1BANK, whereas for conventional-tDCS it was clustered in M1CROWN. The difference in radial inward current in functionally distinct subregions of M1 raises the testable hypothesis that PA-tDCS and conventional-tDCS modulate cortical excitability through different mechanisms. We show that electrode locations can be used to closely approximate current direction in M1 and precentral gyrus, providing a landmark-based method for tDCS application to address the hypothesis without the need for MRI. By contrast, ML-tDCS current was more tangentially orientated, which is associated with weaker somatic polarisation. Substantial inter-individual variability in current direction likely contributes to variable neuromodulation effects reported for these protocols, emphasising the need for individualised electrode montages, including the control of current direction.
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DOI：
10.1109/embc.2012.6347465
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Dmochowski JP;Bikson M;Datta A;Richardson J;Fridriksson J;Parra LC
通讯作者：
Parra LC
影响因子：
2.1
作者：
Dular, P;Geuzaine, C;Legros, N
通讯作者：
Legros, N
影响因子：
7.7
作者：
Farahani F;Kronberg G;FallahRad M;Oviedo HV;Parra LC
通讯作者：
Parra LC
影响因子：
7.7
作者：
Antonenko, Dania;Thielscher, Axel;Floeel, Agnes
通讯作者：
Floeel, Agnes
影响因子：
6.6
作者：
Csifcsak, Gabor;Boayue, Nya Mehnwolo;Mittner, Matthias
通讯作者：
Mittner, Matthias