Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.
Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.
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DOI：
10.1002/mds.26251
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发表时间：
2015-08
影响因子：
8.6
通讯作者：
Schuff, Norbert
中科院分区：
文献类型：
--
作者：
Zhang, Yu;Wu, I-Wei;Buckley, Shannon;Coffey, Christopher S.;Foster, Eric;Mendick, Susan;Seibyl, John;Schuff, Norbert
关键词：
Parkinson’s disease (PD) is histopathologically characterized by the loss of dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing a dysregulation in striatal activity that ultimately leads to lack of movement control. Based on diffusion tensor imaging, visualizing this pathway and measuring alterations of the fiber integrity remain challenging. The objectives were to: 1) develop a diffusion tensor tractography protocol for reliably tracking the nigrostriatal fibers on multicenter data; 2) test whether the integrities measured by diffusion tensor imaging of the nigrostriatal fibers are abnormal in PD; 3) test if abnormal integrities of the nigrostriatal fibers in PD patients are associated with the severity of motor disability and putaminal dopamine binding ratios. Diffusion tensor tractography was performed on 50 drug naïve PD patients and 27 healthy control subjects from the international multicenter Parkinson’s Progression Marker Initiative. Tractography consistently detected the nigrostriatal fibers, yielding reliable diffusion measures. Fractional anisotropy, along with radial and axial diffusivity of the nigrostriatal tract, showed systematic abnormalities in patients. In addition, variations in fractional anisotropy and radial diffusivity of the nigrostriatal tract were associated with the degree of motor deficits in PD patients. Taken together, the findings imply that the diffusion tensor imaging characteristic of the nigrostriatal tract is potentially an index for detecting and staging of early PD.
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影响因子：
4.1
作者：
Prakash, Bhaskaran David;Sitoh, Yih-Yian;Au, Wing Lok
通讯作者：
Au, Wing Lok
影响因子：
82.9
作者：
Gill, SS;Patel, NK;Heywood, P
通讯作者：
Heywood, P
DOI：
10.1007/s00259-005-0032-z
发表时间：
2006-04-01
影响因子：
9.1
作者：
Pogarell, O;Koch, W;Tatsch, K
通讯作者：
Tatsch, K
影响因子：
4.2
作者：
Ofori E;Pasternak O;Planetta PJ;Burciu R;Snyder A;Febo M;Golde TE;Okun MS;Vaillancourt DE
通讯作者：
Vaillancourt DE
影响因子：
11
作者：
Chan, L-L;Rumpel, H.;Tan, E-K
通讯作者：
Tan, E-K