Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study.
Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study.
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DOI：
10.1016/j.neurobiolaging.2014.10.029
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发表时间：
2015-02
影响因子：
4.2
通讯作者：
Vaillancourt DE
中科院分区：
文献类型：
--
作者：
Ofori E;Pasternak O;Planetta PJ;Burciu R;Snyder A;Febo M;Golde TE;Okun MS;Vaillancourt DE
弥散磁共振成像的测量反映了帕金森病黑质的变化。然而，在这种情况下，自由水的部分体积效应会使扩散测量产生偏差。双张量扩散模型被引入到量化的自由水的贡献，并消除其对组织微结构的估计的偏差。在这里，我们测试的假设，即自由水是升高的黑质帕金森氏病与对照组相比。这一假设在一项单中心研究中的帕金森病和对照组参与者之间进行了测试，并在使用多台扫描仪的多中心研究中进行了验证。在单部位和多部位研究中，与对照组相比，帕金森病患者黑质后部区域的游离水体积分数增加。我们没有观察到自由水校正的各向异性分数或自由水校正的平均扩散率的变化。我们的研究结果提供了新的证据，即自由水指数反映了帕金森病黑质的改变，这在单部位和多部位队列中都得到了证明。
Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson’s disease. It is the case, however, that partial volume effects from free-water can bias diffusion measurements. The bi-tensor diffusion model was introduced to quantify the contribution of free-water and eliminates its bias on estimations of tissue microstructure. Here, we test the hypothesis that free-water is elevated in the substantia nigra for Parkinson’s disease compared with controls. This hypothesis was tested between large cohorts of Parkinson’s disease and control participants in a single-site study, and validated against a multi-site study using multiple scanners. The fractional volume of free-water was increased in the posterior region of the substantia nigra in Parkinson’s disease compared with controls in both the single-site and multi-site studies. We did not observe changes in either cohort for free-water corrected fractional anisotropy or free-water corrected mean diffusivity. Our findings provide new evidence that the free-water index reflects alteration of the substantia nigra in Parkinson’s disease, and this was evidenced across both single-site and multi-site cohorts.
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DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
DOI：
10.4061/2011/247467
发表时间：
2011-02-15
期刊：
Parkinson's disease
影响因子：
--
作者：
Farooqui T;Farooqui AA
通讯作者：
Farooqui AA
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
--
作者：
Mounsey RB;Teismann P
通讯作者：
Teismann P
影响因子：
4.4
作者：
Ma, SY;Rinne, JO;Rinne, UK
通讯作者：
Rinne, UK