Emerging techniques in stratified designs and continuous gradients for tissue engineering of interfaces.
Emerging techniques in stratified designs and continuous gradients for tissue engineering of interfaces.
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DOI：
10.1007/s10439-010-0033-3
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发表时间：
2010-06
影响因子：
3.8
通讯作者：
Detamore, Michael S.
中科院分区：
文献类型：
--
作者：
Dormer, Nathan H.;Berkland, Cory J.;Detamore, Michael S.
界面组织工程是再生医学的一个新兴分支，工程师面临着开发同时修复一个或多个功能组织系统的方法。用于复杂组织形成的早期和最近的解决方案已经利用分层设计，其中支架制剂被分离成两层或更多层，物理或化学性质离散变化，模拟相应数量的界面组织类型。这种方法已经带来了有希望的结果，沿着无数的再生技术。然而，最新的设计在性能上采用了“连续梯度”，其中支架层之间没有离散的隔离。这篇评论比较了最近的分层方法和新兴的连续分级方法的应用。
Interfacial tissue engineering is an emerging branch of regenerative medicine, where engineers are faced with developing methods for the repair of one or many functional tissue systems simultaneously. Early and recent solutions for complex tissue formation have utilized stratified designs, where scaffold formulations are segregated into two or more layers, with discrete changes in physical or chemical properties, mimicking a corresponding number of interfacing tissue types. This method has brought forth promising results, along with a myriad of regenerative techniques. The latest designs, however, are employing “continuous gradients” in properties, where there is no discrete segregation between scaffold layers. This review compares the methods and applications of recent stratified approaches to emerging continuously graded methods.
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影响因子：
14
作者：
Kokai, Lauren E.;Ghaznavi, Amir M.;Marra, Kacey G.
通讯作者：
Marra, Kacey G.
影响因子：
14
作者：
Hennessy, Kristin M.;Pollot, Beth E.;Clem, William C.;Phipps, Matthew C.;Sawyer, Amber A.;Culpepper, Bonnie K.;Bellis, Susan L.
通讯作者：
Bellis, Susan L.
DOI：
10.1109/memb.2008.928460
发表时间：
2008-09
期刊：
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
影响因子：
--
作者：
Bian W;Bursac N
通讯作者：
Bursac N
影响因子：
14
作者：
Hutmacher, DW
通讯作者：
Hutmacher, DW
影响因子：
4.1
作者：
Kodama, Shohta;Kojima, Koji;Vacanti, Charles A.
通讯作者：
Vacanti, Charles A.