Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications.
Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications.
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肿瘤转移中的中性粒细胞胞外陷阱：病理功能和临床应用
DOI：
10.3390/cancers13112832
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发表时间：
2021-06-06
期刊：
影响因子：
5.2
通讯作者：
Zhuo W
中科院分区：
文献类型：
--
作者：
Chen Q;Zhang L;Li X;Zhuo W
肿瘤相关中性粒细胞构成了肿瘤微环境中浸润性免疫细胞的重要组成部分。中性粒细胞的能力之一是形成中性粒细胞胞外陷阱。最近对肿瘤相关中性粒细胞的研究日益引起人们对中性粒细胞胞外陷阱在肿瘤微环境中的作用的关注。也有一些综述总结了Nets在肿瘤中的促肿瘤作用。本文的创新之处在于对Nets在肿瘤侵袭转移级联中的关键作用进行了具体的总结，并对Nets在临床应用中的潜力进行了概括。摘要中性粒细胞细胞外陷阱(Net)的形成是中性粒细胞通过释放染色质支架以及相关的细胞毒酶和蛋白水解酶进入细胞外空间而捕获和杀灭病原体的能力。蚊帐通常受到病原微生物及其产物、手术压力或缺氧的刺激。有趣的是，最近的一些研究表明，肿瘤细胞可以诱导网络形成，这反过来又使肿瘤细胞恶性。值得注意的是，新出现的研究表明，Net参与增强局部侵袭，增加血管通透性，促进免疫逃逸和定植，从而促进肿瘤转移。在本文中，我们综述了Nets在肿瘤转移级联中的关键作用。我们还概述了Nets作为癌症预后生物标记物和治疗靶点的潜力。
Simple Summary Tumor-associated neutrophils constitute an important portion of the infiltrating immune cells in the tumor microenvironment. One of the abilities of neutrophils is forming neutrophil extracellular traps. Recent studies on tumor-associated neutrophils have drawn increasing attention to the role of neutrophil extracellular traps in the tumor microenvironment. There were also some reviews summarize the pro-tumorigenic activity of NETs in tumors. The specific novelty of this article is the specific summarization on the pivotal roles of NETs in tumor invasion-metastasis cascade and the recapitulation on the potential of NETs in clinical applications. Abstract Neutrophil extracellular trap (NET) formation is an ability of neutrophils to capture and kill pathogens by releasing chromatin scaffolds, along with associated cytotoxic enzymes and proteases, into the extracellular space. NETs are usually stimulated by pathogenic microorganisms and their products, surgical pressure or hypoxia. Interestingly, a number of recent studies suggest that tumor cells can induce NET formation, which in turn confers tumor cell malignancy. Notably, emerging studies indicate that NETs are involved in enhancing local invasion, increasing vascular permeability and facilitating immune escape and colonization, thus promoting tumor metastasis. In this article, we review the pivotal roles of NETs in the tumor metastasis cascade. We also recapitulate the potential of NETs as a cancer prognostic biomarker and therapeutic target.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
他莫昔芬通过调节细胞内神经酰胺来增强中性粒细胞的先天免疫功能。
影响因子：
16.6
作者：
Corriden R;Hollands A;Olson J;Derieux J;Lopez J;Chang JT;Gonzalez DJ;Nizet V
通讯作者：
Nizet V
DOI：
10.1007/s00018-014-1683-3
发表时间：
2014-11
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Cools-Lartigue J;Spicer J;Najmeh S;Ferri L
通讯作者：
Ferri L
影响因子：
7.3
作者：
Berger-Achituv S;Brinkmann V;Abed UA;Kühn LI;Ben-Ezra J;Elhasid R;Zychlinsky A
通讯作者：
Zychlinsky A
影响因子：
11.2
作者：
Cedervall, Jessica;Zhang, Yanyu;Olsson, Anna-Karin
通讯作者：
Olsson, Anna-Karin