Fluoride-Releasing Effect of a Modified Resin Denture Containing S-PRG Fillers on Salivary Fluoride Retention: A Randomized Clinical Study.
Fluoride-Releasing Effect of a Modified Resin Denture Containing S-PRG Fillers on Salivary Fluoride Retention: A Randomized Clinical Study.
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DOI：
10.1159/000490627
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发表时间：
2019
期刊：
影响因子：
4.2
通讯作者：
Chan DCN
中科院分区：
文献类型：
--
作者：
Kiatsirirote K;Sitthisettapong T;Phantumvanit P;Chan DCN
本研究旨在评价含20 wt % S-PRG（表面预反应玻璃离子）填充剂的树脂基托对唾液氟浓度的影响，作为龋病控制的替代评价。该研究是一项双盲随机临床试验，共有110名年龄在35-60岁的参与者戴用可摘局部树脂义齿1.5年。受试者被随机分配接受部分树脂义齿制作或不含20重量%的S-PRG填料（n=55每组）。戴上假牙14天后，每晚在假牙两侧涂抹5000 ppm氟化物凝胶，然后每晚将其储存在假牙盒中过夜，持续1.5年。唾液氟浓度测定在基线，在第1，14，15天，并在3个月和1.5年戴假牙。从基线到第1天，观察到含S-PRG义齿组唾液氟浓度显著增加，随后显著降低至接近基线水平。用5，000 ppm氟化物凝胶重新充电后，唾液氟化物在第15天显著增加，并在第3个月至1.5年期间保持升高。含20 wt % S-PRG填充剂的树脂基托表现出初始氟释放，增加唾液氟浓度，但从材料内的氟释放是短暂的。从义齿中持续释放氟化物的长期效果与定期的氟化物补充方案相结合，可能有利于预防龋齿。[ClinicalTrials.gov，注册号NCT 02460562]
This study aimed to evaluate the clinical effect of resin denture base containing 20wt% S-PRG (surface pre-reacted glass-ionomer) fillers on saliva fluoride concentration as surrogate evaluation of caries control. The study was a double blind randomized clinical trial with a total of 110 participants aged 35–60 years who wore a removable partial resin denture for 1.5 years. Subjects were randomly assigned to receive a partial resin denture fabricated either with or without 20wt% S-PRG fillers (n=55 per group). After 14 days of wearing the dentures, 5000 ppm fluoride gel was applied nightly on both sides of the denture before storing it in a denture box overnight every night for 1.5 years. Salivary fluoride concentration was measured at baseline, at days 1, 14, 15, and at 3 months and 1.5 years of wearing the denture. A significant increase in salivary fluoride concentration in the S-PRG containing denture group was observed from baseline to Day 1, followed by a significant decrease to an approximate baseline level. After recharge with 5,000 ppm fluoride gel, salivary fluoride increased markedly at Day 15 and remained elevated at month 3 through 1.5 years. The resin denture base containing 20wt% S-PRG fillers demonstrated initial fluoride release that increased saliva fluoride concentration, but the fluoride release from within the material was short-lived. The long term effect of sustained fluoride release from the denture when combined with a regular fluoride recharge regimen may be beneficial for caries prevention. [ClinicalTrials.gov, registration number NCT 02460562]
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