Umbilical Vein Pulse Wave Spectral Analysis: A Possible Method for Placental Assessment Through Evaluation of Maternal and Fetal Flow Components.
Umbilical Vein Pulse Wave Spectral Analysis: A Possible Method for Placental Assessment Through Evaluation of Maternal and Fetal Flow Components.
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DOI：
10.1002/jum.15927
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发表时间：
2022-10
影响因子：
2.3
通讯作者：
Kripfgans, Oliver D.
中科院分区：
文献类型：
--
作者：
Rubin, Jonathan M.;Fowlkes, J. Brian;Pinter, Stephen Z.;Treadwell, Marjorie C.;Kripfgans, Oliver D.
胎盘血流由于具有母体和胎儿血流成分而变得复杂，这使得胎盘功能分析变得困难。使用脐静脉多普勒频谱包络的快速傅立叶变换（FFT），我们能够同时评估胎盘中的母体和胎儿血流，并研究是否可以区分正常和宫内生长受限（IUGR）/先兆子痫妊娠。这是一项回顾性研究，包括正常妊娠（N=11）和宫内生长受限、先兆子痫或两者兼而有之的妊娠（N=13）。脐静脉超声脉冲波频谱采集使用临床扫描仪。光谱包络被确定为时间的函数，并通过傅立叶分析进行分析。鉴别母体和胎儿血流成分。在正常和IUGR/先兆子痫人群中比较母体和胎儿光谱峰比率（LRSP）的基础10个单位（双尾t检验）。还比较了体重指数（BMI）、扫描时的孕龄、胎儿体重、胎盘位置和体重标准化脐静脉血流量（双尾t检验，方差分析（ANOVA））。P < 0.05被认为是显著的。正常妊娠和IUGR/先兆子痫妊娠的LRSP分别为0.141±0.180和−0.072±0.262（平均值±标准差）（p=0.033）。我们还能够检测正常妊娠与LRSP和体重标准化脐静脉血流量组合之间的差异。在先兆子痫和IUGR病例中，基于LRSP和血流的胎盘效应可能协同作用（p=0.014）。LRSP与BMI、扫描时孕周、胎儿体重、胎盘位置无显著相关性（P>0.05）。在这项初步研究中，我们发现脐静脉多普勒频谱包含与胎盘母体和胎儿血流相关的标记物，这些标记物可用于评估IUGR和先兆子痫疾病状态。此外，当与脐带血流量相结合时，这种新的标记物可能会识别这两种情况的主要原因。
Placental blood flow is complicated by having maternal and fetal flow components, which makes placental function analysis difficult. Using the Fast Fourier Transform (FFT) of the envelope of umbilical venous Doppler spectra, we were able to simultaneously assess both maternal and fetal blood flow in the placenta and investigated if normal and intrauterine growth restriction (IUGR)/pre-eclamptic pregnancies could be distinguished. This is a retrospective study including normal gestations (N=11) and gestations with intrauterine growth restriction, pre-eclampsia, or both (N=13). Umbilical vein ultrasound pulsed wave spectra were acquired using clinical scanners. Spectral envelopes were identified as a function of time and analyzed by Fourier analysis. Maternal and fetal flow components were identified. Base 10 logarithms of the ratios of the maternal and fetal spectral peaks (LRSP) were compared in normal and IUGR/pre-eclamptic populations (two-tailed t test). Comparisons were also made with body mass index (BMI), gestational age at the time of scanning, fetal weight, placental position, and weight-normalized umbilical vein blood volume flow (two-tailed t test, analysis of variance (ANOVA). P < 0.05 were considered significant. The LRSP for normal and IUGR/pre-eclamptic pregnancies were 0.141±0.180 and −0.072±0.262 (mean ± standard deviation) respectively (p=0.033). We were also able to detect differences between normal gestations and combinations of LRSP and weight-normalized umbilical venous blood flows. Placental effects based on LRSPs and blood flow may act synergistically in cases with both pre-eclampsia and IUGR (p=0.014). There were no significant associations between LRSP and BMI, gestational age at the time of scanning, fetal weight, and placental position (P>0.05). In this preliminary study, we showed that umbilical venous Doppler spectra contain markers related to placental maternal and fetal blood flow, and that these markers can be used to assess IUGR and pre-eclamptic disease states. Further, when coupled with umbilical cord blood flow, this new marker may potentially identify the primary causes of the two conditions.
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影响因子：
19.7
作者：
Rubin, JM;Bude, RO;Adler, RS
通讯作者：
Adler, RS
影响因子：
19.7
作者：
RUBIN, JM;ADLER, RS;CARSON, PL
通讯作者：
CARSON, PL
影响因子：
4.6
作者：
Osmanski, Bruno-Felix;Lecarpentier, Edouard;Tanter, Mickael
通讯作者：
Tanter, Mickael
DOI：
10.1002/jum.15411
发表时间：
2021-03
期刊：
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
影响因子：
--
作者：
Rubin JM;Li S;Fowlkes JB;Sethuraman S;Kripfgans OD;Shi W;Treadwell MC;Jago JR;Leichner RD;Pinter SZ
通讯作者：
Pinter SZ
影响因子：
7.1
作者：
Parra-Saavedra, M.;Crovetto, F.;Figueras, F.
通讯作者：
Figueras, F.