Stage-Specific Gender Differences in Cognitive and Neuropsychiatric Manifestations of Vascular Dementia
Stage-Specific Gender Differences in Cognitive and Neuropsychiatric Manifestations of Vascular Dementia
复制标题
血管性痴呆认知和神经精神表现的阶段性性别差异
DOI：
10.1177/1533317512454712
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Jia, Jianping
中科院分区：
文献类型：
--
作者：
Wu, Liyong;Song, Haiqing;Zuo, Xiumei;Wang, Fen;Qin, Wei;Li, Dan;Tang, Yi;Jia, Xiang-Fei;Jia, Jianping
血管性痴呆（VaD）临床表现的性别差异研究仍然缺乏。在本研究中，在467例VaD患者中，分别对轻度和中度至重度VaD的认知和神经精神特征进行了性别比较。除轻度阶段女性在即时言语回忆上优于男性外，其他认知表现无显著性别差异。在轻度阶段，女性更容易表现出妄想（15.5% vs 7.4%）、幻觉（9.5% vs 3.4%）和抑郁（43.1% vs 27.3%）。中重度情感淡漠以男性患者居多（50.5%比34.8%）。总之，VaD的神经精神症状存在性别差异，在轻度阶段尤为明显。在轻度VaD中，女性的妄想、幻觉和抑郁更为普遍，而男性仅在后期的冷漠中占优势。
Studies on gender differences in the clinical manifestations of vascular dementia (VaD) are still lacking. In the present study, gender comparisons of cognitive and neuropsychiatric profiles were conducted separately for mild and moderate-to-severe VaD in a total of 467 patients with VaD. There were no significant gender differences in cognitive manifestations, except that females performed better on immediate verbal recall than males in mild stage. Women were more likely to exhibit delusions (15.5% vs 7.4%), hallucinations (9.5% vs 3.4%), and depression (43.1% vs 27.3%) in mild stage. The predominance of male patients was observed in apathy at moderate-to-severe stage (50.5% vs 34.8%). To conclude, gender differences existed in neuropsychiatric symptoms of VaD and were especially pronounced in mild stage. Delusions, hallucinations, and depression were more prevalent in females in mild VaD, with the male predominance only in apathy in the later stage.
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影响因子：
4.8
作者：
McLean CP;Asnaani A;Litz BT;Hofmann SG
通讯作者：
Hofmann SG
影响因子：
5
作者：
Nishiwaki, Y;Breeze, E;Fletcher, AE
通讯作者：
Fletcher, AE
影响因子：
6.6
作者：
KESSLER, RC;MCGONAGLE, KA;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
9.9
作者：
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通讯作者：
D. Ripich;S. Petrill;P. Whitehouse;Elaine W. Ziol
影响因子：
9.9
作者：
Tiraboschi, P;Hansen, LA;Corey-Bloom, J
通讯作者：
Corey-Bloom, J