Role of stem cells in cardiovascular biology.
Role of stem cells in cardiovascular biology.
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DOI：
10.1111/j.1538-7836.2011.04363.x
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Anversa P
中科院分区：
文献类型：
--
作者：
Hosoda T;Rota M;Kajstura J;Leri A;Anversa P
这篇综述文章讨论了关于成人心脏是否具有内在生长储备的争论。如果肌细胞更新发生在健康和病变器官中，那么在病理性损伤中丢失的受损组织的重建可能通过增强自然发生的过程来实现。支持心脏生物学新旧观点的证据被批判性地讨论，试图理解心脏是静态还是动态的器官。根据传统的观念，心脏发挥它的功能，直到有机体死亡与出生时存在相同或更少数量的细胞。细胞周期激活、核分裂和细胞分裂在肌细胞亚群中的记录挑战了这一范式。这些观察结果提出了复制肌细胞起源的重要问题。在这篇综述文章中提出了几种理论。新形成的肌细胞可能来源于已经存在的细胞池，这些细胞池保持了分裂的能力。另外，心肌细胞也可以通过常驻心脏干细胞的激活和承托，或通过远端器官祖细胞的迁移而产生。在所有情况下，整个生命周期的实质细胞更新导致由年轻、成年和衰老肌细胞组成的异质群体。随着时间的推移，衰老肌细胞的积累对心脏功能有不利影响，并可能导致衰老性肌病的发展。
This review article addresses the controversy as to whether the adult heart possesses an intrinsic growth reserve. If myocyte renewal takes place in healthy and diseased organs, the reconstitution of the damaged tissue lost upon pathological insults might be achieved by enhancing a natural occurring process. Evidence in support of the old and new view of cardiac biology is critically discussed in an attempt to understand whether the heart is a static or dynamic organ. According to the traditional concept, the heart exerts its function until death of the organism with the same or lesser number of cells that are present at birth. This paradigm was challenged by documentation of the cell cycle activation and nuclear and cellular division in a subset of myocytes. These observations raised the important question of the origin of replicating myocytes. Several theories have been proposed and are presented in this review article. Newly formed myocytes may derive from a pre-existing pool of cells that has maintained the ability to divide. Alternatively, myocytes may be generated by activation and commitment of resident cardiac stem cells or by migration of progenitor cells from distant organs. In all cases, parenchymal cell turnover throughout lifespan results in a heterogeneous population consisting of young, adult, and senescent myocytes. With time, accumulation of old myocytes has detrimental effects on cardiac performance and may cause the development of an aging myopathy.
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影响因子：
3.7
作者：
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通讯作者：
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作者：
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通讯作者：
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