Chemokine function in periodontal disease and oral cavity cancer.
Chemokine function in periodontal disease and oral cavity cancer.
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DOI：
10.3389/fimmu.2015.00214
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发表时间：
2015
影响因子：
7.3
通讯作者：
Yeudall WA
中科院分区：
文献类型：
--
作者：
Sahingur SE;Yeudall WA
趋化性细胞因子或趋化因子包含具有广泛活性的多肽超家族，所述活性包括将免疫细胞募集至感染和炎症部位以及刺激细胞增殖。因此，它们作为抗微生物分子发挥作用，并在宿主防御病原体攻击中发挥核心作用。然而，它们募集白细胞和增强或延长炎症反应的能力可能对口腔疾病的进展具有深远的影响，例如慢性牙周炎，其中组织破坏可能是广泛的。此外，人们越来越认识到慢性炎症是肿瘤进展的关键组成部分。癌细胞与其微环境之间的相互作用在很大程度上由分泌因子如趋化因子介导，并且用于增强口腔癌和其他癌症中的恶性表型。在本文中，我们将概述趋化因子在牙周病和口腔癌中宿主-微生物组相互作用的生物学和生化机制，以及这些机制如何重叠并有助于发病机制。
The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor progression. Interaction between cancer cells and their microenvironment is mediated in large part by secreted factors such as chemokines, and serves to enhance the malignant phenotype in oral and other cancers. In this article, we will outline the biological and biochemical mechanisms of chemokine action in host–microbiome interactions in periodontal disease and in oral cancer, and how these may overlap and contribute to pathogenesis.
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