State of the evidence 2017: an update on the connection between breast cancer and the environment.
State of the evidence 2017: an update on the connection between breast cancer and the environment.
复制标题
DOI：
10.1186/s12940-017-0287-4
复制
发表时间：
2017-09-02
期刊：
影响因子：
--
通讯作者：
Rizzo J
中科院分区：
文献类型：
--
作者：
Gray JM;Rasanayagam S;Engel C;Rizzo J
在这篇综述中，我们研究了不断扩大和越来越引人注目的数据，这些数据将我们环境中的辐射和各种化学物质与目前乳腺癌的高发病率联系起来。这些有毒物质单独或结合起来，可能对过去几十年中观察到的乳腺癌发病率的增加起到了重要作用。从妊娠到青春期和成年早期的发育早期暴露尤其令人关切，因为它们重新塑造了发育中的乳腺系统中的遗传、表观遗传和生理过程的程序，导致患乳腺癌的风险增加。自我们上次发表相关文献的全面综述以来的8年中，出现了数百篇支持这一联系的新论文，在这次更新中，关于这一主题的证据比以前更广泛，质量更好。流行病学研究中越来越多的证据，以及对有毒物质与乳腺癌发病机制的更好理解，都加强了这样的结论，即接触这些物质-其中许多存在于常见的日常产品和副产品中-可能导致患乳腺癌的风险增加。展望未来，需要注意方法上的局限性，特别是在相关的流行病学和动物模型中，以便能够评估更明确和更直接的联系。
In this review, we examine the continually expanding and increasingly compelling data linking radiation and various chemicals in our environment to the current high incidence of breast cancer. Singly and in combination, these toxicants may have contributed significantly to the increasing rates of breast cancer observed over the past several decades. Exposures early in development from gestation through adolescence and early adulthood are particularly of concern as they re-shape the program of genetic, epigenetic and physiological processes in the developing mammary system, leading to an increased risk for developing breast cancer. In the 8 years since we last published a comprehensive review of the relevant literature, hundreds of new papers have appeared supporting this link, and in this update, the evidence on this topic is more extensive and of better quality than that previously available. Increasing evidence from epidemiological studies, as well as a better understanding of mechanisms linking toxicants with development of breast cancer, all reinforce the conclusion that exposures to these substances – many of which are found in common, everyday products and byproducts – may lead to increased risk of developing breast cancer. Moving forward, attention to methodological limitations, especially in relevant epidemiological and animal models, will need to be addressed to allow clearer and more direct connections to be evaluated.
登录
查看更多内容
共轭性雌激素和乳腺癌的发病率和乳腺癌的死亡率以及子宫切除术后妇女：妇女健康计划的扩展随访随机性安慰剂对照试验。
DOI：
10.1016/s1470-2045(12)70075-x
发表时间：
2012-05
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Anderson GL;Chlebowski RT;Aragaki AK;Kuller LH;Manson JE;Gass M;Bluhm E;Connelly S;Hubbell FA;Lane D;Martin L;Ockene J;Rohan T;Schenken R;Wactawski-Wende J
通讯作者：
Wactawski-Wende J
影响因子：
120.7
作者：
Ambrosone, CB;Freudenheim, JL;Shields, PG
通讯作者：
Shields, PG
影响因子：
3.9
作者：
Ambrosone, Christine B.;Abrams, Sara M.;Kadlubar, Fred F.
通讯作者：
Kadlubar, Fred F.
在大鼠中，围产期给予双足A作为潜在的乳腺癌。
影响因子：
10.4
作者：
Acevedo N;Davis B;Schaeberle CM;Sonnenschein C;Soto AM
通讯作者：
Soto AM
影响因子：
3.8
作者：
Anderson, Kristin N.;Schwab, Richard B.;Martinez, Maria Elena
通讯作者：
Martinez, Maria Elena