Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease.
Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease.
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DOI：
10.1038/s41598-020-74673-x
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发表时间：
2020-10-19
影响因子：
4.6
通讯作者：
Suzuki Y
中科院分区：
文献类型：
--
作者：
Yabuuchi J;Ueda S;Yamagishi SI;Nohara N;Nagasawa H;Wakabayashi K;Matsui T;Yuichiro H;Kadoguchi T;Otsuka T;Gohda T;Suzuki Y
肌肉减少症在慢性肾脏病（CKD）患者中的患病率较高，尤其是在透析患者中。与CKD相关的各种病理状况，如慢性炎症、胰岛素抵抗和内皮功能障碍，被认为与肌肉减少症的发生和进展相关。晚期糖基化终末产物（AGE）是尿毒症的代表性毒素之一，已被证明可导致多种CKD相关并发症。本研究分别研究了AGE在CKD患者和动物的虚弱和肌肉减少症中的作用。在接受透析的患者中，血清AGE水平根据虚弱状态而显著升高，并且与身体表现和活动呈负相关。AGE在5/6肾切除小鼠腓肠肌中积累，并伴有形态学异常、毛细血管稀疏和线粒体功能障碍，所有这些均被针对AGE的DNA适体完全抑制。我们目前的研究结果可能提示AGE在CKD的肌肉减少和虚弱中的病理作用。
Prevalence of sarcopenia is high in patients with chronic kidney disease (CKD), especially in those with dialysis. Various pathological conditions related to CKD, such as chronic inflammation, insulin resistance, and endothelial dysfunction, are thought to be associated with the development and progression of sarcopenia. Advanced glycation end products (AGE), one of the representative uremic toxins, have been shown to contribute to various CKD-associated complications. This study investigated the role of AGE in frailty and sarcopenia in patients and animals with CKD, respectively. In patients undergoing dialysis, serum AGE levels were significantly increased according to the frailty status and inversely associated with physical performance and activity. AGE accumulated in the gastrocnemius muscle of 5/6 nephrectomy mice in association with morphological abnormalities, capillary rarefaction, and mitochondrial dysfunction, all of which were completely inhibited by DNA-aptamer raised against AGE. Our present findings may suggest the pathological role of AGE in sarcopenia and frailty in CKD.
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影响因子：
2.6
作者：
de la Maza, Maria Pia;Uribarri, Jaime;Bunout, Daniel
通讯作者：
Bunout, Daniel
DOI：
10.1093/gerona/gln018
发表时间：
2009-01
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Dalal M;Ferrucci L;Sun K;Beck J;Fried LP;Semba RD
通讯作者：
Semba RD
DOI：
10.1196/annals.1333.088
发表时间：
2005-01-01
期刊：
MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE
影响因子：
--
作者：
Jandeleit-Dahm, KA;Lassila, M;Allen, TJ
通讯作者：
Allen, TJ
DOI：
10.1152/ajpendo.2000.278.2.e219
发表时间：
2000-02-01
影响因子：
5.1
作者：
Adey, D;Kumar, R;Nair, KS
通讯作者：
Nair, KS
DOI：
10.1016/j.numecd.2010.11.008
发表时间：
2012-09-01
影响因子：
3.9
作者：
Leonardis, D.;Basta, G.;Zoccali, C.
通讯作者：
Zoccali, C.