Suppression and Rebound of Pallidal Beta Power: Observation Using a Chronic Sensing DBS Device.
Suppression and Rebound of Pallidal Beta Power: Observation Using a Chronic Sensing DBS Device.
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DOI：
10.3389/fnhum.2021.749567
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发表时间：
2021
影响因子：
2.9
通讯作者：
de Hemptinne C
中科院分区：
文献类型：
--
作者：
Cagle JN;Wong JK;Johnson KA;Foote KD;Okun MS;de Hemptinne C
苍白球脑深部电刺激（DBS）是一种越来越多地用于治疗帕金森病（PD）的疗法。在此，我们研究了DBS对植入新型脉冲发生器（Medtronic Percept系统）的PD患者的苍白球振荡活动以及症状严重程度的影响，该脉冲发生器可通过植入的DBS电极导线促进局部场电位（LFP）的长期记录。在单极配置中使用逐步增量（0.5 mA，每20 s）输送刺激时记录苍白球LFP。在每个刺激幅度下，计算功率谱密度（PSD），并计算β功率（13-30 Hz），并将其与运动迟缓的程度相关联。当输送治疗性刺激时，苍白球β功率降低。β功率与运动迟缓的严重程度相关。当过度刺激时，帕金森综合征的恶化与β频段功率的反弹有关。这些初步结果表明，苍白球β功率可能被用作PD疾病状态的客观标志物。从植入的神经接口的大脑传感的使用可能在未来促进临床编程。检测反弹有助于优化受益，并最大限度地减少过度刺激导致的恶化。
Pallidal deep brain stimulation (DBS) is an increasingly used therapy for Parkinson’s disease (PD). Here, we study the effect of DBS on pallidal oscillatory activity as well as on symptom severity in an individual with PD implanted with a new pulse generator (Medtronic Percept system) which facilitates chronic recording of local field potentials (LFP) through implanted DBS lead. Pallidal LFPs were recorded while delivering stimulation in a monopolar configuration using stepwise increments (0.5 mA, every 20 s). At each stimulation amplitude, the power spectral density (PSD) was computed, and beta power (13–30 Hz) was calculated and correlated with the degree of bradykinesia. Pallidal beta power was reduced when therapeutic stimulation was delivered. Beta power correlated to the severity of bradykinesia. Worsening of parkinsonism when excessive stimulation was applied was associated with a rebound in the beta band power. These preliminary results suggest that pallidal beta power might be used as an objective marker of the disease state in PD. The use of brain sensing from implanted neural interfaces may in the future facilitate clinical programming. Detection of rebound could help to optimize benefits and minimize worsening from overstimulation.
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影响因子：
11.2
作者：
Okun, Michael S.;Fernandez, Hubert H.;Wu, Samuel S.;Kirsch-Darrow, Lindsey;Bowers, Dawn;Bova, Frank;Suelter, Michele;Jacobson, Charles E.;Wang, Xinping;Gordon, Clifford W., Jr.;Zeilman, Pam;Romrell, Janet;Martin, Pam;Ward, Herbert;Rodriguez, Ramon L.;Foote, Kelly D.
通讯作者：
Foote, Kelly D.
影响因子：
5.3
作者：
Eisinger, Robert S.;Cagle, Jackson N.;Gunduz, Aysegul
通讯作者：
Gunduz, Aysegul
影响因子：
158.5
作者：
Follett, Kenneth A.;Weaver, Frances M.;Reda, Domenic J.
通讯作者：
Reda, Domenic J.
影响因子：
4.8
作者：
Foote, KD;Sanchez, JC;Okun, MS
通讯作者：
Okun, MS
影响因子：
5.3
作者：
Ray, N. J.;Jenkinson, N.;Aziz, T.
通讯作者：
Aziz, T.