Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database.
Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database.
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DOI：
10.1002/hep.24397
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发表时间：
2011-08
期刊：
影响因子：
13.5
通讯作者：
McGlynn, Katherine A.
中科院分区：
文献类型：
--
作者：
Welzel, Tania M.;Graubard, Barry I.;Zeuzem, Stefan;El-Serag, Hashem B.;Davila, Jessica A.;McGlynn, Katherine A.
在美国，肝细胞癌（HCC）和肝内胆管细胞癌（ICC）的发病率有所增加。代谢综合征被认为是HCC的危险因素，也是ICC的假定危险因素。然而，风险的大小尚未在美国人群水平上进行研究。因此，我们研究了代谢综合征与这些癌症发生之间的关联。1993年至2005年间诊断为HCC和ICC的所有患者均在监测、流行病学和最终结果（SEER）-医疗保险数据库中进行了识别。为了进行比较，选择了居住在与病例SEER登记相同地区的5%个体样本。根据美国国家胆固醇教育计划成人治疗组III标准定义的代谢综合征患病率，以及HCC的其他风险因素（B型肝炎病毒、丙型肝炎病毒、酒精性肝病、肝硬化、胆汁性肝硬化、血色素沉着症、威尔逊病）和ICC（胆汁性肝硬化、胆管炎、胆石症、胆总管囊肿、B型肝炎病毒、丙型肝炎病毒、酒精性肝病、肝硬化，炎症性肠病）在患癌症和未患癌症的人中进行了比较。Logistic回归用于计算比值比和95%置信区间。3649例HCC病例、743例ICC病例和195,953例对照人群符合纳入标准。代谢综合征在HCC（37.1%）和ICC（29.7%）患者中的发生率明显高于对照组（17.1%，p<0.0001）。在调整后的多元logistic回归分析中，代谢综合征与HCC（优势比=2.13; 95%CI=1.96-2.31，p<0.0001）和ICC（优势比=1.56; 95%CI = 1.32-1.83，p<0.0001）的风险增加显著相关。代谢综合征是美国普通人群发生HCC和ICC的重要危险因素。
Incidence rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor for HCC and a postulated one for ICC. The magnitude of risk, however, has not been investigated on a population level in the U.S. We therefore examined the association between metabolic syndrome and the development of these cancers. All persons diagnosed with HCC and ICC between 1993 and 2005 were identified in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. For comparison, a 5% sample of individuals residing in the same regions as the SEER registries of the cases was selected. The prevalence of metabolic syndrome as defined by the U.S. National Cholesterol Education Program Adult Treatment Panel III criteria, and other risk factors for HCC (hepatitis B virus, hepatitis C virus, alcoholic liver disease, liver cirrhosis, biliary cirrhosis, hemochromatosis, Wilson’s disease) and ICC (biliary cirrhosis, cholangitis, cholelithiasis, choledochal cysts, hepatitis B virus, hepatitis C virus, alcoholic liver disease, cirrhosis, inflammatory bowel disease) were compared among persons who developed cancer and those who did not. Logistic regression was used to calculate odds ratios and 95% confidence intervals. The inclusion criteria were met by 3649 HCC cases, 743 ICC cases and 195,953 comparison persons. Metabolic syndrome was significantly more common among persons who developed HCC (37.1%) and ICC (29.7%) than the comparison group (17.1%, p<0.0001). In adjusted multiple logistic regression analyses, metabolic syndrome remained significantly associated with increased risk of HCC (odds ratio=2.13; 95%CI=1.96–2.31, p<0.0001) and ICC (odds ratio=1.56; 95% CI= 1.32–1.83, p<0.0001). Metabolic syndrome is a significant risk factor for development of HCC and ICC in the general U.S. population.
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影响因子：
29.4
作者：
Davila, JA;Morgan, RO;El-Serag, HB
通讯作者：
El-Serag, HB
DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
Grundy, Scott M.
DOI：
10.1111/j.1440-1746.2005.04058.x
发表时间：
2005-12-01
影响因子：
4.1
作者：
Fan, JG;Zhu, JN;Chen, SY
通讯作者：
Chen, SY
胆管癌：发病机理，诊断和治疗的进展。
影响因子：
13.5
作者：
Blechacz, Boris;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.