The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching.
The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching.
复制标题
DOI：
10.1016/j.devcel.2010.02.019
复制
发表时间：
2010-06-15
影响因子：
11.8
通讯作者：
Tessier-Lavigne, Marc
中科院分区：
文献类型：
--
作者：
Hao, Joe C.;Adler, Carolyn E.;Mebane, Leslie;Gertler, Frank B.;Bargmann, Cornelia I.;Tessier-Lavigne, Marc
神经元通过从主轴突轴中长出轴突分支来神经支配多个目标。我们在此表明，腹侧引导因子 unc-6 (Netrin)、其受体 unc-40 (DCC) 和基因 madd-2 刺激线虫化学感觉和机械感觉神经元的腹侧轴突分支。 madd-2 还促进对 UNC-6 有吸引力的轴突引导，并协助新生轴突中肌动蛋白调节剂 MIG-10 的 unc-6 和 unc-40 依赖性腹侧募集。 MADD-2 是一种与 MID-1 相关的三联基序蛋白，MID-1 是人类发育障碍 Opitz 综合征的致病基因。 MADD-2 和 UNC-40 蛋白优先定位于需要其功能的腹侧轴突分支；遗传结果表明 MADD-2 增强 UNC-40 活性。我们的结果将 MADD-2 确定为轴突吸引和分支中的 UNC-40 辅助因子，与 UNC-5 在排斥中的作用平行，并提供证据表明针对特定轴突分支的引导因子可以赋予对引导线索的差异反应性。
Neurons innervate multiple targets by sprouting axon branches from a primary axon shaft. We show here that the ventral guidance factor unc-6 (Netrin), its receptor unc-40 (DCC), and the gene madd-2 stimulate ventral axon branching in C. elegans chemosensory and mechanosensory neurons. madd-2 also promotes attractive axon guidance to UNC-6 and assists unc-6- and unc-40-dependent ventral recruitment of the actin regulator MIG-10 in nascent axons. MADD-2 is a tripartite motif protein related to MID-1, the causative gene for the human developmental disorder Opitz syndrome. MADD-2 and UNC-40 proteins preferentially localize to a ventral axon branch that requires their function; genetic results indicate that MADD-2 potentiates UNC-40 activity. Our results identify MADD-2 as an UNC-40 cofactor in axon attraction and branching, paralleling the role of UNC-5 in repulsion, and provide evidence that targeting of a guidance factor to specific axonal branches can confer differential responsiveness to guidance cues.
登录
查看更多内容
影响因子：
5.3
作者：
Dent, EW;Barnes, AM;Kalil, K
通讯作者：
Kalil, K
影响因子：
64.5
作者：
Chan, SSY;Zheng, H;Culotti, JG
通讯作者：
Culotti, JG
影响因子：
16.2
作者：
ISHII, N;WADSWORTH, WG;HEDGECOCK, EM
通讯作者：
HEDGECOCK, EM
影响因子：
4.6
作者：
Alexander, Mariam;Chan, Kevin Ka Ming;Roy, Peter John
通讯作者：
Roy, Peter John
影响因子：
25
作者：
Adler, CE;Fetter, RD;Bargmann, CI
通讯作者：
Bargmann, CI