A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
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DOI：
10.1016/j.eururo.2019.09.006
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发表时间：
2020-04
期刊：
影响因子：
23.4
通讯作者：
Bladder Cancer Molecular Taxonomy Group
中科院分区：
文献类型：
--
作者：
Kamoun A;de Reyniès A;Allory Y;Sjödahl G;Robertson AG;Seiler R;Hoadley KA;Groeneveld CS;Al-Ahmadie H;Choi W;Castro MAA;Fontugne J;Eriksson P;Mo Q;Kardos J;Zlotta A;Hartmann A;Dinney CP;Bellmunt J;Powles T;Malats N;Chan KS;Kim WY;McConkey DJ;Black PC;Dyrskjøt L;Höglund M;Lerner SP;Real FX;Radvanyi F;Bladder Cancer Molecular Taxonomy Group
肌层浸润性膀胱癌（MIBC）是一种分子多样性疾病，临床结局各异。已经提出了几种分子分类，但其亚型集的多样性阻碍了其临床应用。就MIBC分子亚型达成国际共识，以协调已发表的分类方案。我们使用了来自16个已发表数据集和两个额外队列的1750个MIBC转录组学图谱。我们对六个独立的MIBC分类系统进行了基于网络的分析，以确定分子类别的共识集。使用多变量考克斯模型评估与生存期的相关性。我们报告的结果，国际努力达成共识的MIBC分子亚型。我们确定了一组共有的6种分子类型：管腔乳头状（24%）、管腔未指明（8%）、管腔不稳定（15%）、基质丰富（15%）、基底/鳞状（35%）和神经内分泌样（3%）。这些共识类别在潜在的致癌机制、免疫和基质细胞浸润以及组织学和临床特征（包括结局）方面存在差异。我们提供了一个单样本分类器，它为肿瘤样本的转录组分配了一个共识类标签。这项工作的局限性是回顾性的临床数据收集和缺乏关于患者治疗的完整信息。这种共识系统提供了一个强大的框架，将使预测生物标志物在未来的前瞻性临床试验中的测试和验证。膀胱癌在分子水平上是异质性的，科学家们已经提出了几种分子类别的分类。虽然这些分类可能有助于对患者进行预后或对治疗的反应分层，但共识分类将促进分子分类的临床使用。本研究由该领域的多学科专家团队进行，提出了这样的共识，并提供了在临床环境中应用共识分类的工具。
Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application. To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes. We used 1750 MIBC transcriptomic profiles from 16 published datasets and two additional cohorts. We performed a network-based analysis of six independent MIBC classification systems to identify a consensus set of molecular classes. Association with survival was assessed using multivariable Cox models. We report the results of an international effort to reach a consensus on MIBC molecular subtypes. We identified a consensus set of six molecular classes: luminal papillary (24%), luminal nonspecified (8%), luminal unstable (15%), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%). These consensus classes differ regarding underlying oncogenic mechanisms, infiltration by immune and stromal cells, and histological and clinical characteristics, including outcomes. We provide a single-sample classifier that assigns a consensus class label to a tumor sample’s transcriptome. Limitations of the work are retrospective clinical data collection and a lack of complete information regarding patient treatment. This consensus system offers a robust framework that will enable testing and validation of predictive biomarkers in future prospective clinical trials. Bladder cancers are heterogeneous at the molecular level, and scientists have proposed several classifications into sets of molecular classes. While these classifications may be useful to stratify patients for prognosis or response to treatment, a consensus classification would facilitate the clinical use of molecular classes. Conducted by multidisciplinary expert teams in the field, this study proposes such a consensus and provides a tool for applying the consensus classification in the clinical setting.
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影响因子：
4.6
作者：
Aine M;Eriksson P;Liedberg F;Sjödahl G;Höglund M
通讯作者：
Höglund M
影响因子：
28.2
作者：
Pal SK;Rosenberg JE;Hoffman-Censits JH;Berger R;Quinn DI;Galsky MD;Wolf J;Dittrich C;Keam B;Delord JP;Schellens JHM;Gravis G;Medioni J;Maroto P;Sriuranpong V;Charoentum C;Burris HA;Grünwald V;Petrylak D;Vaishampayan U;Gez E;De Giorgi U;Lee JL;Voortman J;Gupta S;Sharma S;Mortazavi A;Vaughn DJ;Isaacs R;Parker K;Chen X;Yu K;Porter D;Graus Porta D;Bajorin DF
通讯作者：
Bajorin DF
影响因子：
10.3
作者：
Mo, Qianxing;Nikolos, Fotis;Chan, Keith Syson
通讯作者：
Chan, Keith Syson
影响因子：
2
作者：
Horsman MR;Overgaard J
通讯作者：
Overgaard J
DOI：
10.3233/blc-150037
发表时间：
2016-01-07
期刊：
Bladder cancer (Amsterdam, Netherlands)
影响因子：
--
作者：
Lerner SP;McConkey DJ;Hoadley KA;Chan KS;Kim WY;Radvanyi F;Höglund M;Real FX
通讯作者：
Real FX