Identification and characterization of host factors involved in plant RNA virus replication
Identification and characterization of host factors involved in plant RNA virus replication
复制标题
植物 RNA 病毒复制涉及的宿主因子的鉴定和表征
DOI：
10.1007/s10327-021-01022-9
复制
发表时间：
2021
影响因子：
1.2
通讯作者：
Hyodo K
中科院分区：
文献类型：
--
作者：
Mai Mohsen Ahmed Abdelghany;Maria Kurikawa;Megumi Watanabe;Hidenori Matsui;Mikihiro Yamamoto;Yuki Ichinose;Kazuhiro Toyoda;Yusuke Kouzai;Yoshiteru Noutoshi;Hyodo K
植物病毒占植物病害的近一半，每年造成的经济损失估计超过300亿美元。正义（+）单链（ss）RNA病毒是最丰富的植物病毒类型，并且通常是全世界重要经济作物的破坏性病原体。绝大多数植物（+）ssRNA病毒是包含编码少于20种蛋白质的核酸基因组的非常简单的实体。由于病毒编码的蛋白质数量有限，（+）ssRNA病毒需要重新利用宿主的细胞机制来实现自身功能，最终创造一个有利于其感染的细胞环境。为此，（+）ssRNA植物病毒会吸收一系列宿主衍生因子（称为前病毒宿主因子），重塑其功能，以建立病毒感染并促进病毒生命周期的每一步（Hyodo和Okuno 2020; Wang 2015）。因此，宿主前病毒因子的鉴定对于了解病毒如何操纵宿主细胞以建立感染至关重要。为了破译植物-病毒相互作用的分子网络，我主要研究了由红三叶草坏死花叶病毒（RCNMV）（Hyodo和Kaido 2021）及其宿主本氏烟草（Nicotiana benthamiana）组成的病理系统。这篇综述概述了这一领域的一些最新研究结果，将提供深入了解宿主-病毒相互作用。
Plant viruses account for nearly a half of the plant diseases and cause estimated economic losses of more than US $30 billion annually. Positive-sense (+) single-stranded (ss) RNA viruses are the most abundant type of plant viruses and often are destructive pathogens of economically important crops worldwide. The vast majority of plant (+) ssRNA viruses are very simple entities comprising a nucleic acid genome encoding fewer than 20 proteins. Because of the limited number of virus-encoded proteins,(+) ssRNA viruses need to repurpose the host’s cell machinery for their own functions, ultimately creating a cellular environment favorable to their infection. For this purpose,(+) ssRNA plant viruses co-opt an array of host-derived factors (referred to as proviral host factors), remodeling their functions to allow the establishment of viral infection and to facilitate every step of the viral life cycle (Hyodo and Okuno 2020; Wang 2015). Therefore, the identification of host proviral factors is critical for understanding how the virus manipulates the host cell to establish infection. To decipher the molecular network of plant–virus interactions, I have been working largely on the pathosystem consisting of red clover necrotic mosaic virus (RCNMV)(Hyodo and Kaido 2021) and its host Nicotiana benthamiana. This review outlines some of the recent findings in this area that will provide insights into host–virus interactions.
影响因子：
5.2
作者：
Zhenlu Zhang;Guijuan He;N. Filipowicz;G. Randall;G. Belov;B. G. Kopek;Xiaofeng Wang
通讯作者：
Zhenlu Zhang;Guijuan He;N. Filipowicz;G. Randall;G. Belov;B. G. Kopek;Xiaofeng Wang
DOI：
10.1146/annurev-virology-092818-015748
发表时间：
2019-01-01
期刊：
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
影响因子：
--
作者：
Ketter, Ellen;Randall, Glenn
通讯作者：
Randall, Glenn
影响因子：
6.7
作者：
Zhang Z;He G;Han GS;Zhang J;Catanzaro N;Diaz A;Wu Z;Carman GM;Xie L;Wang X
通讯作者：
Wang X