The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression.
The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression.
复制标题
丧亲与健康的心理生物学：从社会信号转导理论的角度来看，概念回顾。
DOI：
10.3389/fpsyt.2020.565239
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发表时间：
2020
影响因子：
4.7
通讯作者：
Slavich GM
中科院分区：
文献类型：
--
作者：
Seiler A;von Känel R;Slavich GM
失去配偶被认为是一个人能经历的最有压力的生活事件之一。特别是在失去亲人后的几周和几个月内，丧亲之痛与发病率和死亡率的风险显著增加有关。尽管进行了大量的研究，旨在确定导致婚姻死亡后不良健康结果的风险因素，但人们对丧亲之痛后出现精神和身体健康问题的机制仍然知之甚少。为了解决这一问题，本综述研究了可能与丧亲之痛和健康有关的几种途径，包括炎症和免疫失调、遗传和表观遗传变化、肠道微生物群活性和生物衰老。然后，我们描述了如何从抑郁症的社会信号转导理论的角度来看待这些过程，以提供一个新的框架来理解个体在适应人际损失的长期轨迹上的差异。最后，我们讨论了将丧亲之痛与身心健康结果联系起来的心理生物学机制的未来研究的几种途径。
Losing a spouse is considered one of the most stressful life events a person can experience. Particularly in the immediate weeks and months after the loss, bereavement is associated with a significantly increased risk of morbidity and mortality. Despite an abundance of research aimed at identifying risk factors for adverse health outcomes following marital death, the mechanisms through which mental and physical health problems emerge following bereavement remain poorly understood. To address this issue, the present review examines several pathways that may link bereavement and health, including inflammation and immune dysregulation, genetic and epigenetic changes, gut microbiota activity, and biological aging. We then describe how these processes may be viewed from the perspective of the Social Signal Transduction Theory of Depression to provide a novel framework for understanding individual differences in long-term trajectories of adjustment to interpersonal loss. Finally, we discuss several avenues for future research on psychobiological mechanisms linking bereavement with mental and physical health outcomes.
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影响因子：
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影响因子：
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DOI：
10.1146/annurev-clinpsy-032210-104526
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