Multi-Scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced Myopia.
Multi-Scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced Myopia.
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DOI：
10.1007/s10659-016-9603-4
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发表时间：
2017-12
影响因子：
2
通讯作者：
El Hamdaoui M
中科院分区：
文献类型：
--
作者：
Grytz R;El Hamdaoui M
在发育过程中，巩膜使用未知的机制来使眼轴长度与其光学元件相匹配，从而产生具有良好焦点的眼睛（正视）。近视眼的眼睛太长了，不适合自己的光学系统。我们提出了一个多尺度的计算模型来模拟眼睛发育的假设，即巩膜生长是由遗传因素控制，而巩膜重塑是由遗传因素和眼睛的屈光不正。我们将生长定义为改变组织体积和质量的机制，而重塑涉及在宏观尺度上保持体积的内部微变形。该模型与不同年龄的树鼩的纵向屈光测量值拟合，并暴露于三种不同的视觉条件：（i）正常发育;（ii）负透镜佩戴诱导近视;和（iii）通过去除负透镜从近视中恢复。该模型能够复制树鼩实验的年龄和视觉依赖性反应。巩膜生长停止在年轻的年龄比巩膜重塑。模型的预测能力通过计算树鼩对巩膜重塑的敏感性和对形觉剥夺性近视的反应来研究。这两个预测都与未用于拟合模型的实验数据吻合良好。我们提出了第一个区分巩膜生长与重塑的模型。我们的结果与实验数据的良好一致性支持了巩膜生长和巩膜重塑是眼睛发育过程中两个独立控制机制的观点。
The sclera uses unknown mechanisms to match the eye’s axial length to its optics during development, producing eyes with good focus (emmetropia). A myopic eye is too long for its own optics. We propose a multi-scale computational model to simulate eye development based on the assumption that scleral growth is controlled by genetic factors while scleral remodeling is driven by genetic factors and the eye’s refractive error. We define growth as a mechanism that changes the tissue volume and mass while remodeling involves internal micro-deformations that are volume-preserving at the macroscale. The model was fitted against longitudinal refractive measurements in tree shrews of different ages and exposed to three different visual conditions: (i) normal development; (ii) negative lens wear to induce myopia; and (iii) recovery from myopia by removing the negative lens. The model was able to replicate the age- and vision-dependent response of the tree shrew experiments. Scleral growth ceased at younger age than scleral remodeling. The remodeling rate decreased as the eye emmetropized but increased at any age when a negative lens was put on. The predictive power of the model was investigated by calculating the susceptibility to scleral remodeling and the response to form deprivation myopia in tree shrews. Both predictions were in good agreement with experimental data that were not used to fit the model. We propose the first model that distinguishes scleral growth from remodeling. The good agreement of our results with experimental data supports the notion that scleral growth and scleral remodeling are two independently controlled mechanisms during eye development.
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DOI：
10.1115/1.3113682
发表时间：
2009-05
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Girard MJ;Downs JC;Burgoyne CF;Suh JK
通讯作者：
Suh JK
影响因子：
2.4
作者：
Grytz R;Girkin CA;Libertiaux V;Downs JC
通讯作者：
Downs JC
影响因子：
2.9
作者：
Backhouse, Simon;Fox, Stephanie;Phillips, John R.
通讯作者：
Phillips, John R.
影响因子：
2
作者：
Bryant, MR;McDonnell, PJ
通讯作者：
McDonnell, PJ
DOI：
10.1016/j.ijengsci.2014.08.003
发表时间：
2014-12-01
影响因子：
6.6
作者：
Cyron, C. J.;Humphrey, J. D.
通讯作者：
Humphrey, J. D.