Perspectives on biomechanical growth and remodeling mechanisms in glaucoma().
Perspectives on biomechanical growth and remodeling mechanisms in glaucoma().
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DOI：
10.1016/j.mechrescom.2012.01.007
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发表时间：
2012-06
影响因子：
2.4
通讯作者：
Downs JC
中科院分区：
文献类型：
--
作者：
Grytz R;Girkin CA;Libertiaux V;Downs JC
青光眼是一种致盲疾病，轴突受损导致视网膜神经节细胞丢失。实验证据表明，慢性眼压升高在筛板水平启动轴突损伤。筛板是一种多孔的胶原蛋白结构，轴突通过它从视网膜进入大脑。最近的实验研究发现，在青光眼的发生发展过程中，筛板及其周围组织发生了广泛的结构变化。本文综述了青光眼生长和重塑机制的实验证据，包括组织各向异性适应、组织增厚/变薄、组织延长/缩短和组织迁移。我们讨论了现有的预测计算方法，试图阐明这些生长和重塑机制的潜在生物力学基础，并强调开放的问题、挑战和进一步发展的途径。
Glaucoma is a blinding diseases in which damage to the axons results in loss of retinal ganglion cells. Experimental evidence indicates that chronic intraocular pressure elevation initiates axonal insult at the level of the lamina cribrosa. The lamina cribrosa is a porous collagen structure through which the axons pass on their path from the retina to the brain. Recent experimental studies revealed the extensive structural changes of the lamina cribrosa and its surrounding tissues during the development and progression of glaucoma. In this perspective paper we review the experimental evidence for growth and remodeling mechanisms in glaucoma including adaptation of tissue anisotropy, tissue thickening/thinning, tissue elongation/shortening and tissue migration. We discuss the existing predictive computational approaches that try to elucidate the potential biomechanical basis of theses growth and remodeling mechanisms and highlight open questions, challenges, and avenues for further development.
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DOI：
10.1115/1.3113682
发表时间：
2009-05
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Girard MJ;Downs JC;Burgoyne CF;Suh JK
通讯作者：
Suh JK
影响因子：
5.7
作者：
Aghamohammadzadeh, H;Newton, RH;Meek, KM
通讯作者：
Meek, KM
影响因子：
2
作者：
Bryant, MR;McDonnell, PJ
通讯作者：
McDonnell, PJ
DOI：
10.1016/j.jmbbm.2008.12.009
发表时间：
2009-10-01
影响因子：
3.9
作者：
Grytz, Rafael;Meschke, Guenther
通讯作者：
Meschke, Guenther
影响因子：
--
作者：
GOLDBAUM, MH;JENG, S;WEINREB, RN
通讯作者：
WEINREB, RN