Study on cerebral microcirculation by Optical Doppler Tomography

Study on cerebral microcirculation by Optical Doppler Tomography
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光学多普勒断层扫描脑微循环研究

DOI:
10.1007/s11433-008-0186-3
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发表时间:
2008-11
期刊:
Science in China Series G-Physics Mechanics & Astronomy
影响因子:
--
通讯作者:
Meng Jie
Meng Jie
中科院分区:
其他
文献类型:
--
作者:
Guo ZhouYi;Yang Yong;Ding ZhiHua;Meng Jie

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光学多普勒断层扫描(ODT)为测量直径为微米的血管血流速度提供了一种新的方法。以颅窗大鼠为模型,采用建立的ODT系统,在电刺激和给药的情况下,实时测量感觉皮层脑小动脉血流速度的变化。结果显示实验组与对照组的血流速度有显著差异,证明了ODT在脑微循环研究中的可行性。与传统的多普勒超声相比,ODT提供了更高的空间分辨率,因此在脑微循环研究,特别是在微米尺度血管血流速度的观察中具有广阔的应用前景。
Optical Doppler Tomography (ODT) provides a novel method to measure the blood flow velocity in vessels with the diameter at micrometer scale. Rats with cranial window are used as a model, and the changes in the blood flow velocity of cerebral arterioles in sensory cortex are measured in real time with an established ODT system, under electrical stimulation and drug administration. The results show significant differences in the blood flow velocity between experimental groups and control groups, demonstrating the feasibility of ODT in the cerebral microcirculation study. Compared with the conventional Doppler ultrasound, ODT provides much higher spatial resolution, and thus holds a promising future in the application of the cerebral microcirculation study, especially in the observation of the blood flow velocity in micrometer scale vessels.
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期刊: --
影响因子: --
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