A Human Depression Circuit Derived From Focal Brain Lesions.
A Human Depression Circuit Derived From Focal Brain Lesions.
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DOI：
10.1016/j.biopsych.2019.07.023
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发表时间：
2019-11-15
影响因子：
10.6
通讯作者：
Fox MD
中科院分区：
文献类型：
--
作者：
Padmanabhan JL;Cooke D;Joutsa J;Siddiqi SH;Ferguson M;Darby RR;Soussand L;Horn A;Kim NY;Voss JL;Naidech AM;Brodtmann A;Egorova N;Gozzi S;Phan TG;Corbetta M;Grafman J;Fox MD
局灶性脑损伤可以帮助我们深入了解人类大脑中抑郁症的神经解剖学基础。然而，病变位置的研究导致了不一致的结果。整理了5个具有不同病变病因和病变后抑郁测量的独立数据集（N = 461）。每个3D病变位置被映射到一个共同的大脑图谱。我们使用体素病变症状映射来测试抑郁症和病变位置之间的关联。接下来，我们使用大型规范连接组数据集（N = 1000）计算功能上连接到每个病变位置的区域网络。我们使用这些损伤网络图来测试抑郁症和连接的大脑回路之间的关联。使用严格的留一法验证评估重现性。最后，我们测试了与抑郁症相关的病变位置是否与脑刺激部位有效改善卒中后抑郁症的电路相同。与抑郁症相关的病变部位是高度异质性的，没有一个单一的大脑区域始终受到牵连。然而，这些相同的病变位置映射到一个连接的大脑回路，集中在左背外侧前额叶皮层。结果是稳健的，可以排除一个数据集的交叉验证。最后，我们的抑郁回路来源于与脑刺激部位一致的脑损伤，这些部位对改善中风后抑郁有效。与抑郁症相关的病变部位无法映射到特定的大脑区域，但确实映射到特定的大脑回路。该电路可能在识别中风后抑郁风险患者方面具有预后效用，并且在细化脑刺激靶点方面具有治疗效用。
Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. However, studies of lesion location have led to inconsistent results. Five independent datasets with different lesion etiologies and measures of post-lesion depression were collated (N = 461). Each 3D lesion location was mapped to a common brain atlas. We used voxel lesion symptom mapping to test for associations between depression and lesion locations. Next, we computed the network of regions functionally connected to each lesion location using a large normative connectome dataset (N = 1000). We used these lesion network maps to test for associations between depression and connected brain circuits. Reproducibility was assessed using a rigorous leave-one-dataset-out validation. Finally, we tested whether lesion locations associated with depression fell within the same circuit as brain stimulation sites effective for improving post-stroke depression. Lesion locations associated with depression were highly heterogeneous, and no single brain region was consistently implicated. However, these same lesion locations mapped to a connected brain circuit, centered on the left dorsolateral prefrontal cortex. Results were robust to leave one-dataset-out cross-validation. Finally, our depression circuit derived from brain lesions aligned with brain stimulation sites effective for improving post-stroke depression. Lesion locations associated with depression fail to map to a specific brain region but do map to a specific brain circuit. This circuit may have prognostic utility in identifying patients at risk for post-stroke depression and therapeutic utility in refining brain stimulation targets.
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影响因子：
9.8
作者：
Holmes, Avram J.;Hollinshead, Marisa O.;O'Keefe, Timothy M.;Petrov, Victor I.;Fariello, Gabriele R.;Wald, Lawrence L.;Fischl, Bruce;Rosen, Bruce R.;Mair, Ross W.;Roffman, Joshua L.;Smoller, Jordan W.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
病变网络的犯罪行为本地化。
DOI：
10.1073/pnas.1706587115
发表时间：
2018-01-16
影响因子：
11.1
作者：
Darby RR;Horn A;Cushman F;Fox MD
通讯作者：
Fox MD
影响因子：
16.2
作者：
Corbetta M;Ramsey L;Callejas A;Baldassarre A;Hacker CD;Siegel JS;Astafiev SV;Rengachary J;Zinn K;Lang CE;Connor LT;Fucetola R;Strube M;Carter AR;Shulman GL
通讯作者：
Shulman GL
影响因子：
5.7
作者：
Fox MD;Liu H;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
10.6
作者：
George, MS;Nahas, Z;Ballenger, JC
通讯作者：
Ballenger, JC