Lesion network localization of criminal behavior.
Lesion network localization of criminal behavior.
复制标题
病变网络的犯罪行为本地化。
DOI：
10.1073/pnas.1706587115
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发表时间：
2018-01-16
影响因子：
11.1
通讯作者：
Fox MD
中科院分区：
文献类型：
--
作者：
Darby RR;Horn A;Cushman F;Fox MD
像查尔斯惠特曼这样的案件，他在脑瘤生长后谋杀了16人，引发了关于为什么一些大脑病变，而不是其他病变，可能导致犯罪行为的争论。在这里，我们系统地描述这种病变，并将其与引起其他症状的病变进行比较。我们发现多个不同脑区的病变与犯罪行为有关。然而，这些病变都属于一个独特的功能连接的大脑网络，涉及道德决策。此外，与竞争性大脑网络的连接预测了在这些患者中观察到的异常道德决策。这些结果提供了深入了解为什么一些大脑病变，而不是其他人，可能倾向于犯罪行为，具有潜在的神经科学，医学和法律的影响。在脑部病变后，以前正常的患者有时会表现出犯罪行为。虽然罕见，但这些病例可以为犯罪的神经生物学基础提供独特的见解。在这里，我们提出了一个系统的映射与已知的时间关联的病变的犯罪行为，确定17病变的情况下。病变部位在空间上是异质的，包括内侧前额叶皮质、眶额皮质以及双侧颞叶内的不同位置。在所有病例中，没有一个脑区受损。由于病变引起的症状可能来自与病变部位相连的部位，而不仅仅是病变部位本身，我们还确定了与每个病变部位功能相关的大脑区域。这种技术，被称为病变网络映射，最近已确定在各种病变引起的疾病的症状产生所涉及的区域。所有病变在功能上都连接到相同的脑区网络。与其他四种神经精神综合征的病变相比，这种与犯罪相关的连接模式是独特的。这个网络包括涉及道德、基于价值的决策和心理理论的区域，但不包括涉及认知控制或移情的区域。最后，我们在一个单独的23例病例中重复了我们的结果，其中脑损伤和犯罪行为之间的时间关系是隐含的，但不是确定的。我们的研究结果表明，罪犯的病变发生在不同的大脑位置，但定位于一个独特的静息状态网络，提供了深入了解犯罪行为的神经生物学。
Cases like that of Charles Whitman, who murdered 16 people after growth of a brain tumor, have sparked debate about why some brain lesions, but not others, might lead to criminal behavior. Here we systematically characterize such lesions and compare them with lesions that cause other symptoms. We find that lesions in multiple different brain areas are associated with criminal behavior. However, these lesions all fall within a unique functionally connected brain network involved in moral decision making. Furthermore, connectivity to competing brain networks predicts the abnormal moral decisions observed in these patients. These results provide insight into why some brain lesions, but not others, might predispose to criminal behavior, with potential neuroscience, medical, and legal implications. Following brain lesions, previously normal patients sometimes exhibit criminal behavior. Although rare, these cases can lend unique insight into the neurobiological substrate of criminality. Here we present a systematic mapping of lesions with known temporal association to criminal behavior, identifying 17 lesion cases. The lesion sites were spatially heterogeneous, including the medial prefrontal cortex, orbitofrontal cortex, and different locations within the bilateral temporal lobes. No single brain region was damaged in all cases. Because lesion-induced symptoms can come from sites connected to the lesion location and not just the lesion location itself, we also identified brain regions functionally connected to each lesion location. This technique, termed lesion network mapping, has recently identified regions involved in symptom generation across a variety of lesion-induced disorders. All lesions were functionally connected to the same network of brain regions. This criminality-associated connectivity pattern was unique compared with lesions causing four other neuropsychiatric syndromes. This network includes regions involved in morality, value-based decision making, and theory of mind, but not regions involved in cognitive control or empathy. Finally, we replicated our results in a separate cohort of 23 cases in which a temporal relationship between brain lesions and criminal behavior was implied but not definitive. Our results suggest that lesions in criminals occur in different brain locations but localize to a unique resting state network, providing insight into the neurobiology of criminal behavior.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
4.6
作者：
Ermer, Elsa;Cope, Lora M.;Nyalakanti, Prashanth K.;Calhoun, Vince D.;Kiehl, Kent A.
通讯作者：
Kiehl, Kent A.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
de Oliveira-Souza, Ricardo;Hare, Robert D.;Moll, Jorge
通讯作者：
Moll, Jorge
影响因子：
6.4
作者：
Bufkin, JL;Luttrell, VR
通讯作者：
Luttrell, VR