PSF: nuclear busy-body or nuclear facilitator?
PSF: nuclear busy-body or nuclear facilitator?
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DOI：
10.1002/wrna.1280
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发表时间：
2015-07
影响因子：
7.3
通讯作者：
Lynch, Kristen W.
中科院分区：
文献类型：
--
作者：
Yarosh, Christopher A.;Iacona, Joseph R.;Lutz, Carol S.;Lynch, Kristen W.
PTB相关剪接因子(PSF)是一种丰富和必需的核酸结合蛋白，参与了广泛的基因调控过程和细胞反应途径。在蛋白质水平上，PSF由多个结构域组成，其中许多结构域仍未得到很好的描述。尽管根据序列同源性，PSF与蛋白质p54nrb/NONO和PSPC1分在一个家族中，但PSF包含其他家族成员不包括的额外蛋白质序列。一直以来，PSF也与p54nrb/NONO或PSPC1未归因于的功能有关。在这里，我们提供了一个关于PSF参与的细胞活动的综述，以及关于PSF在每个病例中发挥作用的机制的已知情况。我们认为，PSF的复杂领域安排允许其功能的多样性和活动的集成。最后，我们讨论了最近的证据，即PSF的个体活动可以通过领域特定的辅助因子的活动相互独立地调节。《电线RNA 2015》，6：351-367。DOI：10.1002/wrna.1280有关本文的更多资源，请访问WIRESS网站。利益冲突：作者声明没有利益冲突。
PTB‐associated splicing factor (PSF) is an abundant and essential nucleic acid‐binding protein that participates in a wide range of gene regulatory processes and cellular response pathways. At the protein level, PSF consists of multiple domains, many of which remain poorly characterized. Although grouped in a family with the proteins p54nrb/NONO and PSPC1 based on sequence homology, PSF contains additional protein sequence not included in other family members. Consistently, PSF has also been implicated in functions not ascribed to p54nrb/NONO or PSPC1. Here, we provide a review of the cellular activities in which PSF has been implicated and what is known regarding the mechanisms by which PSF functions in each case. We propose that the complex domain arrangement of PSF allows for its diversity of function and integration of activities. Finally, we discuss recent evidence that individual activities of PSF can be regulated independently from one another through the activity of domain‐specific co‐factors. WIREs RNA 2015, 6:351–367. doi: 10.1002/wrna.1280 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors declare no conflict of interest.
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影响因子：
3.3
作者：
Figueroa, Angelica;Kotani, Hirokazu;Fujita, Yasuyuki
通讯作者：
Fujita, Yasuyuki
DOI：
10.1073/pnas.1303445110
发表时间：
2013-07-23
影响因子：
11.1
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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