Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma.
Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma.
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DOI：
10.18632/oncotarget.3005
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发表时间：
2015-02-28
期刊：
影响因子：
--
通讯作者：
Liu FF
中科院分区：
文献类型：
--
作者：
Bruce JP;Hui AB;Shi W;Perez-Ordonez B;Weinreb I;Xu W;Haibe-Kains B;Waggott DM;Boutros PC;O'Sullivan B;Waldron J;Huang SH;Chen EX;Gilbert R;Liu FF
尽管现代鼻咽癌（NPC）治疗在局部控制方面有了显着改善，但患者仍有发生远处转移（DM）的显著风险。识别那些有糖尿病风险的患者将有助于未来的个性化治疗。microRNAs（miRNAs）在人类癌症中起着许多重要作用;因此，我们着手解决存在能够预测NPC患者DM的miRNA表达特征的主要假设。在125个（训练）和121个（验证）临床注释的NPC诊断活检样品中测量734个miRNA的表达。通过将惩罚的考克斯比例风险回归模型拟合到训练数据集（HR 8.25; p < 0.001）来鉴定与发生DM的风险相关的4-miRNA表达特征，并且随后在独立的验证集（HR 3.2; p = 0.01）中进行验证。途径富集分析表明，与DM相关的miRNA的靶点似乎集中在细胞周期途径上。这种4-miRNA标记增加了目前TNM分期的“金标准”的预后价值。对这些4-miRNAs的深入研究将提供重要的生物学见解，有助于发现和开发新的分子靶向疗法，以改善未来NPC患者的预后。
Despite significant improvement in locoregional control in the contemporary era of nasopharyngeal carcinoma (NPC) treatment, patients still suffer from a significant risk of distant metastasis (DM). Identifying those patients at risk of DM would aid in personalized treatment in the future. MicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients. The expression of 734 miRNAs was measured in 125 (Training) and 121 (Validation) clinically annotated NPC diagnostic biopsy samples. A 4-miRNA expression signature associated with risk of developing DM was identified by fitting a penalized Cox Proportion Hazard regression model to the Training data set (HR 8.25; p < 0.001), and subsequently validated in an independent Validation set (HR 3.2; p = 0.01). Pathway enrichment analysis indicated that the targets of miRNAs associated with DM appear to be converging on cell-cycle pathways. This 4-miRNA signature adds to the prognostic value of the current “gold standard” of TNM staging. In-depth interrogation of these 4-miRNAs will provide important biological insights that could facilitate the discovery and development of novel molecularly targeted therapies to improve outcome for future NPC patients.
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影响因子：
4.3
作者：
Beck AH;Knoblauch NW;Hefti MM;Kaplan J;Schnitt SJ;Culhane AC;Schroeder MS;Risch T;Quackenbush J;Haibe-Kains B
通讯作者：
Haibe-Kains B
DOI：
10.1186/bcr2890
发表时间：
2011-06-27
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Colombo PE;Milanezi F;Weigelt B;Reis-Filho JS
通讯作者：
Reis-Filho JS
鼻咽癌中 microRNA 特征的预后价值：microRNA 表达分析
影响因子：
51.1
作者：
Liu, Na;Chen, Nian-Yong;Ma, Jun
通讯作者：
Ma, Jun
影响因子：
14.9
作者：
Hsu SD;Tseng YT;Shrestha S;Lin YL;Khaleel A;Chou CH;Chu CF;Huang HY;Lin CM;Ho SY;Jian TY;Lin FM;Chang TH;Weng SL;Liao KW;Liao IE;Liu CC;Huang HD
通讯作者：
Huang HD
影响因子：
158.5
作者：
Lin, JC;Wang, WY;Jiang, RS
通讯作者：
Jiang, RS