Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.
Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.
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DOI：
10.1016/j.fgb.2009.09.002
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发表时间：
2010-02
影响因子：
3
通讯作者：
Heitman, Joseph
中科院分区：
文献类型：
--
作者：
Reedy, Jennifer L.;Filler, Scott G.;Heitman, Joseph
The protein phosphatase calcineurin is a key mediator of virulence and antifungal susceptibility of multiple fungal pathogens including Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, and has clinical potential as a therapeutic target to increase the efficacy of the current antifungal armamentarium. Despite the importance of this signaling pathway, few components of the calcineurin-signaling pathway are known in C. albicans. Here we identified and analyzed additional components of the C. albicans calcineurin cascade, including the RCN1 (Regulator of Calcineurin1), MID1, and CCH1 genes, which mediate calcineurin functions in other species. When heterologous expressed in S. cerevisiae, C. albicans Rcn1 inhibited calcineurin function. Although rcn1/rcn1, mid1/mid1, and cch1/cch1 mutant strains share some phenotypes with calcineurin mutants, they do not completely recapitulate the phenotypes of a calcineurin mutant strain. These studies extend our understanding of the C. albicans calcineurin signaling cascade and its host-niche specific role in virulence.
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白色念珠菌的菌丝取向受钙依赖性机制调节。
影响因子：
9.2
作者：
Brand, Alexandra;Shanks, Scott;Duncan, Vanessa M. S.;Yang, Meng;Mackenzie, Kevin;Gow, Neil A. R.
通讯作者：
Gow, Neil A. R.
影响因子：
11.4
作者：
CARDENAS, ME;MUIR, RS;HEITMAN, J
通讯作者：
HEITMAN, J
DOI：
10.1083/jcb.124.3.351
发表时间：
1994-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cunningham KW;Fink GR
通讯作者：
Fink GR
影响因子：
11.4
作者：
Görlach, J;Fox, DS;Heitman, J
通讯作者：
Heitman, J
影响因子：
3.1
作者：
Bader, Teresa;Schroeppel, Klaus;Morschhaeuser, Joachim
通讯作者：
Morschhaeuser, Joachim