Effects of Hyperthermia Induced Changes in pH Value on Tumor Response and Thermotolerance
Effects of Hyperthermia Induced Changes in pH Value on Tumor Response and Thermotolerance
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热疗引起的 pH 值变化对肿瘤反应和耐热性的影响
DOI：
10.1007/978-4-431-67035-3_48
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Yoshimasa Tanaka
中科院分区：
文献类型：
--
作者：
T. Hasegawa;Yeun;Tohru Takahashi;Takashi Hasegawa;Yoshimasa Tanaka
在大腿皮下移植FM 3A肿瘤的C3 H小鼠中，通过腹腔注射6 mg/kg葡萄糖诱导高血糖后，观察到肿瘤组织pH的选择性降低。通过将动物置于43°C的温水浴中30分钟进行加热，然后在不同的时间间隔后重复相同的处理。通过葡萄糖给药诱导高血糖后，未加热的肿瘤组织pH值下降0.3至0.6，而未加热的正常组织pH值仅下降0.1至0.2，恢复到先前水平的速度比肿瘤组织慢。在葡萄糖给药后加热时，肿瘤组织pH值在加热后立即从6.9降至6.5，加热后恢复时间延迟。在正常组织中，加热前7.2的组织pH值降至6.9，在热处理后迅速恢复到高于基线的水平。第一次热处理后6 h，葡萄糖组热耐受性达到最大值，12 h后热耐受性消失。在未给予葡萄糖的组中，热耐受性在第一次治疗后12小时达到最大值，甚至在72小时后也没有发生热耐受性的完全丧失。当热处理间隔为12小时时，给予葡萄糖的组的肿瘤生长速度比不给予葡萄糖的组慢4天，表明具有抗肿瘤效果。在第一次给药后的所有时间间隔，与未给药组相比，给予葡萄糖的组显示肿瘤生长延迟1-2天，表明热敏感性增强。葡萄糖给药引起的高血压诱导肿瘤组织pH选择性降低，表明可能诱导肿瘤的选择性热敏感性。
After inducing hyperglycemia by intraperitoneally injecting 6mg/kg glucose in C3H mice transplanted with a FM3A tumor subcutaneously in the thigh, a selective decrease of tumor tissue pH was seen.The frequency of appearance of thermal hypersensitivity and thermotolerance in response to glucose administration was studied. Heating was conducted by placing the animals in a thermostatic water bath at 43°C for 30 min, followed by a repeat of the same treatment after various intervals. After inducing hyperglycemia by glucose administration, nonheated tumor tissue pH decreased by 0.3 to 0.6, whereas pH of nonheated normal tissue fell by only 0.1 to 0.2, with a slower recovery to the previous level than the tumor tissue. On heating after glucose administration, tumor tissue pH fell from 6.9 to 6.5 immediately after heating with a delay of recovery time after heating. In normal tissue, tissue pH of 7.2 before heating fell to 6.9, rapidly recovering to a level higher than the baseline after the heat treatment. Thermotolerance reached a maximum 6h after the first heat treatment in the group given glucose and disappeared after 12 h. In the group not given glucose, thermotolerance reached a maximum 12 h after the first treatment, and no complete loss of thermotolerance occurred even after 72 h. Tumor growth rate in the group given glucose was 4 days slower than in that not given glucose when the interval between heat treatment was 12 h, indicating an antitumor effect. At all intervals after the first, the group given glucose showed a delay of tumor growth by 1–2 days compared to the group not given glucose, indicating augmented heat sensitivity. Hyperglycemia caused by glcose administration induced a selective decrease of tumor tissue pH, indicating the possibility of inducing selective heat sensitivity in tumors.
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影响因子：
11.2
作者：
C. Song
通讯作者：
C. Song
影响因子：
19.7
作者：
BICHER, HI;HETZEL, FW;OBRIEN, T
通讯作者：
OBRIEN, T
影响因子：
19.7
作者：
EDDY, HA
通讯作者：
EDDY, HA
高血糖对小鼠正常组织和肿瘤组织热反应的影响。
影响因子：
11.2
作者：
Urano,M;Montoya,V;Booth,A
通讯作者：
Booth,A
pH 值对细胞对单剂量和分剂量热疗反应的影响。
影响因子：
11.2
作者：
Gerweck,LE;Jennings,M;Richards,B
通讯作者：
Richards,B