Peripheral blood leukocyte telomere length is associated with age but not renal function: A cross-sectional follow-up study
Peripheral blood leukocyte telomere length is associated with age but not renal function: A cross-sectional follow-up study
复制标题
外周血白细胞端粒长度与年龄相关，但与肾功能无关：横断面随访研究
DOI：
10.1007/s12603-017-0905-4
复制
发表时间：
2017
影响因子：
5.8
通讯作者：
Chen XM
中科院分区：
文献类型：
--
作者：
Zhang WG;Jia L P;Ma J;Zhu SY;Nie SS;Song KK;Liu XM;Zhang YP;Cao D;Yang XP;Zhao DL;Xiu MJ;Lin L;Li ZX;Huang Q;Chen X-Z;Chen L;Wang P;Bai X J;Feng Z;Fu B;Huang J;Zhang JP;Cai GY;Sun XF;Chen XM
目的：探讨端粒长度变化与基线肾功能的关系。方法：对2014年招募的健康志愿者进行外周血白细胞端粒限制性片段（TRF）长度测定。根据血清肌酐（Scr）和血清胱抑素C（CysC）-eGFRcys和eGFRScr-cys，通过Cockcroft-Gault公式（eGFRC-G）或慢性肾脏病流行病学协作组（CKD-EPI / eGFRCKD-EPI）公式计算估计的肾小球滤过率（eGFR）。结果：白细胞TRF长度与年龄（r =-0.393，p < 0.001）和血清CysC（r =-0.180，p < 0.01）呈负相关，与eGFRCKD-EPI、eGFRC-G、eGFRcys和eGFRScr-cys呈正相关（r分别为0.182、0.122、0.290和0.254，p < 0.01）。端粒长度3年变化为46个碱基/年。当调整年龄时，端粒长度变化与基线、随后的TRF长度和血清CysC之间的相关性不再存在。结论：端粒长度变化率受年龄和基线端粒长度的影响。端粒长度的变化可能是衰老的重要标志。
Objectives:We aimed to evaluate the relationship between baseline renal function and changes in telomere length in Han Chinese.Methods:The telomere restriction fragment (TRF) length of leukocytes in the peripheral blood was measured in healthy volunteers recruited in 2014. The estimated glomerular filtration rate (eGFR) was calculated based on serum creatinine (Scr) and serum cystatin C (CysC)-eGFRcys and eGFRScr-cys through the Cockcroft-Gault formula (eGFRC-G) or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI / eGFRCKD-EPI) equation. The correlation between telomere length changes over time and renal function was analyzed.Results:Leukocyte TRF lengths were negatively correlated to age (r = -0.393, p < 0.001) and serum CysC (r = -0.180, p < 0.01), while positively associated with eGFRCKD-EPI, eGFRC-G, eGFRcys, and eGFRScr-cys (r = 0.182, 0.122, 0.290, and 0.254 respectively, p < 0.01). The 3-year change of telomere length was 46 bp/years. When adjusted for age, the associations between telomere length changes and baseline, subsequent TRF lengths, and serum CysC were no longer present. No association was observed between TRF length changes and renal function.Conclusion:The rate of telomere length changes was affected by age and baseline telomere length. The telomere length changes might be important markers for aging.
登录
查看更多内容
影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
影响因子：
4.2
作者：
Bansal N;Whooley MA;Regan M;McCulloch CE;Ix JH;Epel E;Blackburn E;Lin J;Hsu CY
通讯作者：
Hsu CY
DOI：
10.1007/s00392-009-0048-7
发表时间：
2009-10
期刊：
Clinical research in cardiology : official journal of the German Cardiac Society
影响因子：
--
作者：
Wong LS;van der Harst P;de Boer RA;Codd V;Huzen J;Samani NJ;Hillege HL;Voors AA;van Gilst WH;Jaarsma T;van Veldhuisen DJ
通讯作者：
van Veldhuisen DJ
影响因子：
7.8
作者：
Koppelstaetter, Christian;Schratzberger, Gabriele;Mayer, Gert
通讯作者：
Mayer, Gert
影响因子：
13.2
作者：
Ramírez, R;Carracedo, J;Aljama, P
通讯作者：
Aljama, P