Therapeutic efficacy of oral immunization with a non-genetically modified Lactococcus lactis-based vaccine CUE-GEM induces local immunity against Helicobacter pylori infection
Therapeutic efficacy of oral immunization with a non-genetically modified Lactococcus lactis-based vaccine CUE-GEM induces local immunity against Helicobacter pylori infection
复制标题
非转基因乳酸乳球菌疫苗 CUE-GEM 口服免疫的治疗效果可诱导针对幽门螺杆菌感染的局部免疫力
DOI：
10.1007/s00253-016-7333-y
复制
发表时间：
2016-02
影响因子：
5
通讯作者：
Xing YY
中科院分区：
文献类型：
--
作者：
Liu Wei;Tan Zhoulin;Xue Jinfeng;Luo Wenjin;Song Hui;Lv Xiaobo;Zheng Tianjing;Xi Tao;Xing Yingying;Liu Wei;Tan Zhoulin;Xue Jinfeng;Luo Wenjin;Song Hui;Zheng Tianjing;Xi T;Xing YY
胃部细菌病原体幽门螺杆菌能持续定殖在人类胃黏膜上，在胃炎、消化性溃疡及胃腺癌的发生发展过程中起着关键作用。因此，根除幽门螺杆菌或许……
（注：原英文最后“the eradication of H. pylori migh”表述有误，推测应为“the eradication of H. pylori might” ，这里按推测内容翻译。）
The gastric bacterial pathogenHelicobacter pyloripersistently colonizes the gastric mucosa of humans and plays a critical role in the development of gastritis, peptic ulceration and gastric adenocarcinoma. Consequently, the eradication ofH. pylorimight contribute to the prevention ofH. pylori-associated gastric diseases. In this study, a multi-epitope vaccine CTB-UE (CUE) was displayed on the surface of non-genetically modifiedLactococcus lactisparticles (GEM) to enhance immunogenicity. This particulate vaccine CUE-GEM induced serum and mucosal specific antibody responses against nativeH. pyloriurease and provided potent protection to eliminateH. pyloricolonization and relieve gastritis in anH. pylori-infected BALB/c mouse model. The immuno-protective mechanisms are highly associated with CD4+Th cell-mediated and humoral immunity, especially local immunity. There might be two main aspects of this association. One aspect is related to the suppression of urease activity by promotion of the production of specific mucosal neutralizing antibody. The other aspect is correlated with alleviating gastritis by regulating the gastric pro-inflammatory cytokine profile, especially IFN-γ and IL-17. These results demonstrated that conjugating antigen vaccines with GEM particles could lead to promising oral therapeutic vaccine formulations againstH. pyloriinfection.
登录
查看更多内容
影响因子：
29.4
作者：
Mohammadi, M;Nedrud, J;Czinn, SJ
通讯作者：
Czinn, SJ
影响因子：
5
作者：
Guo, Le;Yin, Runting;Xing, Yingying
通讯作者：
Xing, Yingying
表位疫苗CTB-UA对BALB/c小鼠模型幽门螺杆菌感染的预防和治疗效果
影响因子：
5
作者：
Guo, Le;Liu, Kunmei;Xi, Tao
通讯作者：
Xi, Tao
影响因子：
5.5
作者：
Wenfeng Zhao;Wutong Wu;Xudong Xu
通讯作者：
Wenfeng Zhao;Wutong Wu;Xudong Xu
影响因子：
5.5
作者：
Xiaobo Lv;Jue Yang;Hui Song;Tong Li;Le Guo;Yingying Xing;Tao Xi
通讯作者：
Xiaobo Lv;Jue Yang;Hui Song;Tong Li;Le Guo;Yingying Xing;Tao Xi