The role of microRNA in head and neck cancer: current knowledge and perspectives.
The role of microRNA in head and neck cancer: current knowledge and perspectives.
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DOI：
10.3390/molecules19055704
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发表时间：
2014-05-05
期刊：
影响因子：
--
通讯作者：
Numico G
中科院分区：
文献类型：
--
作者：
Courthod G;Franco P;Palermo L;Pisconti S;Numico G
头颈癌是世界范围内最常见的恶性肿瘤之一。晚期患者经常出现复发或远处转移，尽管综合治疗取得了相当大的进展，但其5年生存率仍低于60%。更好地了解肿瘤发生的分子基础是改善临床结果和开发新的抗癌药物的必要条件。microRNA（miRNAs）是一类在转录后调节基因表达的非编码小RNA分子。它们是正常生物学过程中的重要调节因子;然而，在许多不同的肿瘤中已经观察到miRNAs的失调，并参与肿瘤的发生。miRNA可以作为肿瘤抑制因子或癌基因。几项关于头颈癌的研究证实了miRNAs的异常表达如何参与增殖、转移、化学抗性和放射抗性。此外，miRNA是极好的生物标志物靶标，因为它们在人体体液中稳定循环，并且可以通过非侵入性方法获得。此外，miRNA的上调和下调与特定的癌症表型（预后不良、侵袭性和治疗抗性）相关，起到预后生物标志物的作用。本文就miRNAs在头颈部肿瘤中的研究进展及其作为药物治疗靶点的可能性作一综述。
Head and neck cancer is one of the most commonly diagnosed malignancies worldwide. Patients with advanced disease stages frequently develop recurrences or distant metastasis, which results a five-year survival rates of less than 60% despite considerable advances in multimodality therapy. A better understanding of molecular basis of tumorigenesis is required to improve clinical outcomes and to develop new anti-cancer drugs. microRNAs (miRNAs) are a class of small, non-coding, RNA molecules that modulate gene expression post-transcriptionally. They are important regulator in normal biological process; however miRNAs deregulation has been observed in many different tumors and is involved in tumorigenesis. miRNAs may act as tumor suppressors or as oncogenes. Several studies on head and neck cancer demonstrated how aberrant expression of miRNAs is involved in proliferation, metastasis, chemoresistence, and radioresistance. In addition, miRNAs are excellent biomarker targets because they circulate stable in human body fluids and can be obtained with non-invasive methods. Moreover, miRNAs up and down regulation has been correlated with specific cancer phenotype (poor prognosis, aggressiveness and resistance to treatment), playing a role as prognostic biomarkers. This review summarizes current finding on miRNAs in head and neck cancer and their potential role as target for next drug therapy.
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影响因子：
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作者：
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DOI：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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作者：
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