Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome.
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DOI:
10.1126/science.1195203
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发表时间:
2010-12-10
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Tyler BM
Tyler BM
中科院分区:
其他
文献类型:
--
作者:
Baxter L;Tripathy S;Ishaque N;Boot N;Cabral A;Kemen E;Thines M;Ah-Fong A;Anderson R;Badejoko W;Bittner-Eddy P;Boore JL;Chibucos MC;Coates M;Dehal P;Delehaunty K;Dong S;Downton P;Dumas B;Fabro G;Fronick C;Fuerstenberg SI;Fulton L;Gaulin E;Govers F;Hughes L;Humphray S;Jiang RHY;Judelson H;Kamoun S;Kyung K;Meijer H;Minx P;Morris P;Nelson J;Phuntumart V;Qutob D;Rehmany A;Rougon-Cardoso A;Ryden P;Torto-Alalibo T;Studholme D;Wang Y;Win J;Wood J;Clifton SW;Rogers J;Van den Ackerveken G;Jones JDG;McDowell JM;Beynon J;Tyler BM

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许多卵菌和真菌植物病原体是专性生物营养体,它们只能从活的植物组织中提取营养,不能离开宿主生长。虽然这些病原菌会造成农作物的重大损失,但人们对专性生物营养的分子基础或进化知之甚少。在这里,我们报道了拟南芥的一种专性的生态型和自然病原菌--卵菌的基因组序列。与相关的半生物营养型疫霉的基因组相比,HPA基因组编码的基因显著减少:1)RXLR效应器和其他分泌的致病蛋白;2)同化无机氮和硫的酶;3)与游动孢子形成和运动相关的蛋白质。这些属性构成了向专性生物营养进化的基因组签名。
Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause significant crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison to genomes of related, hemi-biotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding: 1) RXLR effectors and other secreted pathogenicity proteins; 2) enzymes for assimilation of inorganic nitrogen and sulphur; 3) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution towards obligate biotrophy.
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