Effects of central nervous system electrical stimulation on non-neuronal cells.
Effects of central nervous system electrical stimulation on non-neuronal cells.
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DOI：
10.3389/fnins.2022.967491
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发表时间：
2022
影响因子：
4.3
通讯作者：
Cui, Xinyan Tracy
中科院分区：
文献类型：
--
作者：
Williams, Nathaniel P.;Kushwah, Neetu;Dhawan, Vaishnavi;Zheng, Xin Sally;Cui, Xinyan Tracy
关键词：
在过去的几十年中，中枢神经系统（CNS）电刺激在临床应用方面取得了很大进展，用于治疗从帕金森病（PD）到癫痫等越来越多的疾病，以及用于感觉恢复和许多其他应用。然而，对于细胞水平的微刺激效应知之甚少。现有的大多数研究都集中在电刺激对神经元的影响上。中枢神经系统的其他细胞，如小胶质细胞、星形胶质细胞、少突胶质细胞和血管内皮细胞，在对刺激的反应方面研究不足。这些细胞类型的多样且关键的功能现在开始得到更好的理解，它们在健康和疾病状态下的大脑功能中所起的重要作用也越来越受到重视。为了阐明电刺激（不同于设备植入）对非神经元细胞类型影响方式的重要性，本综述将首先从设备设计和刺激参数的角度总结常见的刺激模式，以及这些不同参数如何对生理反应产生影响。在此之后，将总结不同细胞类型对不同刺激模式的反应的已知情况，参考临床研究以及临床相关动物模型和体外系统的研究结果。
Over the past few decades, much progress has been made in the clinical use of electrical stimulation of the central nervous system (CNS) to treat an ever-growing number of conditions from Parkinson’s disease (PD) to epilepsy as well as for sensory restoration and many other applications. However, little is known about the effects of microstimulation at the cellular level. Most of the existing research focuses on the effects of electrical stimulation on neurons. Other cells of the CNS such as microglia, astrocytes, oligodendrocytes, and vascular endothelial cells have been understudied in terms of their response to stimulation. The varied and critical functions of these cell types are now beginning to be better understood, and their vital roles in brain function in both health and disease are becoming better appreciated. To shed light on the importance of the way electrical stimulation as distinct from device implantation impacts non-neuronal cell types, this review will first summarize common stimulation modalities from the perspective of device design and stimulation parameters and how these different parameters have an impact on the physiological response. Following this, what is known about the responses of different cell types to different stimulation modalities will be summarized, drawing on findings from both clinical studies as well as clinically relevant animal models and in vitro systems.
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影响因子：
12.7
作者：
Bradl M;Lassmann H
通讯作者：
Lassmann H
影响因子：
4.6
作者：
Cancel LM;Arias K;Bikson M;Tarbell JM
通讯作者：
Tarbell JM
DOI：
10.3389/fpain.2021.702906
发表时间：
2021
期刊：
Frontiers in pain research (Lausanne, Switzerland)
影响因子：
--
作者：
Cedeño DL;Kelley CA;Chakravarthy K;Vallejo R
通讯作者：
Vallejo R
影响因子：
3.3
作者：
Bennabi D;Haffen E
通讯作者：
Haffen E
影响因子：
8.3
作者：
Baba, Tanefumi;Kameda, Masahiro;Date, Isao
通讯作者：
Date, Isao