Photoacoustic Computed Tomography of Breast Cancer in Response to Neoadjuvant Chemotherapy.
Photoacoustic Computed Tomography of Breast Cancer in Response to Neoadjuvant Chemotherapy.
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DOI：
10.1002/advs.202003396
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Lin L;Tong X;Hu P;Invernizzi M;Lai L;Wang LV
新辅助化疗（NAC）有助于改善乳腺癌的预后，理想情况下，它将减少NAC治疗后无残留癌患者对确定性乳腺手术的需求。然而，没有可靠的非侵入性成像方式接受作为常规方法来评估对NAC的反应。由于无法检测到完全缓解，NAC后手术仍然是标准治疗。为了克服这一限制，开发了一种单次屏气光声计算机断层扫描（SBH-PACT）系统，以提供与对比增强磁共振成像相似的对比度，但具有更高的空间和时间分辨率，并且无需注射造影剂。SBH-PACT在三个时间点对乳腺癌患者进行成像：NAC之前、期间和之后。通过分析SBH-PACT上的肿瘤大小、血管密度以及血管分布和形态的不规则性，可准确识别对NAC的反应，并经组织病理学诊断证实。SBH-PACT显示其作为诊断工具的近期潜力，通过无创测量癌症相关血管生成的变化来评估乳腺癌对全身治疗的反应。SBH-PACT的进一步发展也可能使连续成像，而不是使用当前的侵入性活检，以诊断和随访不确定的乳腺病变。开发了一种光声成像系统，通过在治疗前、治疗期间和治疗后对乳腺癌患者进行成像，非侵入性地评估乳腺癌对新辅助化疗（NAC）的反应。肿瘤大小、血管密度以及血管分布和形态的不规则性的分析准确地识别了癌症对NAC的反应，如组织病理学诊断所证实的。
Neoadjuvant chemotherapy (NAC) has contributed to improving breast cancer outcomes, and it would ideally reduce the need for definitive breast surgery in patients who have no residual cancer after NAC treatment. However, there is no reliable noninvasive imaging modality accepted as the routine method to assess response to NAC. Because of the inability to detect complete response, post‐NAC surgery remains the standard of care. To overcome this limitation, a single‐breath‐hold photoacoustic computed tomography (SBH‐PACT) system is developed to provide contrast similar to that of contrast‐enhanced magnetic resonance imaging, but with much higher spatial and temporal resolution and without injection of contrast chemicals. SBH‐PACT images breast cancer patients at three time points: before, during, and after NAC. The analysis of tumor size, blood vascular density, and irregularity in the distribution and morphology of the blood vessels on SBH‐PACT accurately identifies response to NAC as confirmed by the histopathological diagnosis. SBH‐PACT shows its near‐term potential as a diagnostic tool for assessing breast cancer response to systemic treatment by noninvasively measuring the changes in cancer‐associated angiogenesis. Further development of SBH‐PACT may also enable serial imaging, rather than the use of current invasive biopsies, to diagnose and follow indeterminate breast lesions. A photoacoustic imaging system is developed to noninvasively assess breast cancer's response to neoadjuvant chemotherapy (NAC) by imaging breast cancer patients before, during, and after therapy. The analysis of tumor size, blood vascular density, and irregularity in the distribution and morphology of the blood vessels accurately identifies cancer's response to NAC as confirmed by the histopathological diagnosis.
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影响因子：
2.9
作者：
Madsen, Ernest L.;Deaner, Meagan E.;Mehi, James
通讯作者：
Mehi, James
影响因子：
16.6
作者：
Lin L;Hu P;Shi J;Appleton CM;Maslov K;Li L;Zhang R;Wang LV
通讯作者：
Wang LV
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作者：
Fukuda T;Horii R;Gomi N;Miyagi Y;Takahashi S;Ito Y;Akiyama F;Ohno S;Iwase T
通讯作者：
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影响因子：
3.8
作者：
Culver, JP;Choe, R;Yodh, AG
通讯作者：
Yodh, AG
影响因子：
158.5
作者：
Cardoso, F.;van't Veer, L. J.;Piccart, M.
通讯作者：
Piccart, M.