Single-breath-hold photoacoustic computed tomography of the breast.
Single-breath-hold photoacoustic computed tomography of the breast.
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DOI：
10.1038/s41467-018-04576-z
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发表时间：
2018-06-15
影响因子：
16.6
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Lin L;Hu P;Shi J;Appleton CM;Maslov K;Li L;Zhang R;Wang LV
我们已经开发了一个单屏气光声计算机断层扫描（SBH-PACT）系统，以揭示详细的血管造影结构在人类乳房。SBH-PACT具有深穿透深度（体内4 cm）和高空间和时间分辨率（255 µm面内分辨率和10 Hz 2D帧率）。通过在单次屏气（~15 s）内扫描整个乳房，可以采集体积图像，随后利用3D反投影重建，呼吸引起的运动伪影可忽略不计。SBH-PACT通过在高空间分辨率下观察与肿瘤相关的较高血管密度，清晰地显示了肿瘤，显示了在放射学致密乳腺中具有高灵敏度的早期前景。除了血管成像之外，高成像速度还可以进行动态研究，例如光声弹性成像，它通过显示较低的顺应性来识别肿瘤。我们对乳房大小从B杯到DD杯不等，皮肤色素从浅到深不等的乳腺癌患者进行成像。SBH-PACT识别了所有的肿瘤，而没有采用电离辐射或外源性造影剂，不会造成健康风险。目前乳腺癌诊断的标准是乳房X线摄影;然而，乳房X线摄影的灵敏度在放射学上致密的乳房中可能较低。在这里，作者开发了一种单次屏气光声计算机断层扫描（SBH-PACT）系统，以揭示人体乳房中详细的血管造影结构，从而可以检测与肿瘤相关的较高血管密度。
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts. SBH-PACT clearly reveals tumors by observing higher blood vessel densities associated with tumors at high spatial resolution, showing early promise for high sensitivity in radiographically dense breasts. In addition to blood vessel imaging, the high imaging speed enables dynamic studies, such as photoacoustic elastography, which identifies tumors by showing less compliance. We imaged breast cancer patients with breast sizes ranging from B cup to DD cup, and skin pigmentations ranging from light to dark. SBH-PACT identified all the tumors without resorting to ionizing radiation or exogenous contrast, posing no health risks. The current standard for breast cancer diagnostic is a mammogram; however, the sensitivity of mammography can be low in radiographically dense breasts. Here the authors develop a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts allowing the detection of higher blood vessel densities associated with tumors.
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影响因子：
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作者：
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