Contrast-Enhanced Ultrasound for Monitoring Non-surgical Treatments of Uterine Fibroids: A Systematic Review.

Contrast-Enhanced Ultrasound for Monitoring Non-surgical Treatments of Uterine Fibroids: A Systematic Review.
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DOI:
10.1016/j.ultrasmedbio.2020.09.016
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发表时间:
2021-01
影响因子:
2.9
通讯作者:
Forsberg F
Forsberg F
中科院分区:
医学3区
文献类型:
--
作者:
Torkzaban M;Machado P;Gupta I;Hai Y;Forsberg F

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子宫肌瘤的非手术治疗选择有子宫动脉栓塞(UAE)、高强度聚焦超声消融(HIFUA)和经皮微波消融(PMWA)。磁共振成像(MRI)是这些程序之前和之后的参考标准成像方法。对比增强超声(CEUS)已被研究作为MRI的替代方法,用于评估肌瘤的特征和对非手术治疗的反应。在PubMed、奥维德Medline和Scopus数据库中检索了2000年1月至2020年6月7日期间研究CEUS作为辅助手段监测UAE、HIFUA或PMWA在人类子宫肌瘤治疗中的应用的英文文献。两名独立评审员分析了128篇出版物,其中17篇被纳入。基于这一系统性综述,CEUS提供了UAE术前、术中和术后有关肌瘤体积和血管化的详细数据,并有助于确定手术终点。使用术中CEUS的HIFUA在较短时间内具有更快的体积收缩,所需能量更少,并可在HIFUA后早期检测残留组织。CEUS和对比增强MRI(CE-MRI)具有足够的一致性,可在临床上交替使用,以评价子宫肌瘤的PMWA和HIFUA的治疗效果。
Nonsurgical treatment options for uterine fibroids are uterine artery embolization (UAE), high intensity focused ultrasound ablation (HIFUA), and percutaneous microwave ablation (PMWA). Magnetic resonance imaging (MRI) is the reference standard imaging method before and after these procedures. Contrast-enhanced ultrasound (CEUS) has been studied as an alternative to MRI for evaluating the fibroids’ characteristics and responses to nonsurgical treatments. English literatures investigating the application of CEUS as an adjunct to monitor UAE, HIFUA or PMWA in uterine fibroid treatments in human were searched in PubMed, Ovid Medline, and Scopus databases from January 2000 through June 7th, 2020. Two independent reviewers analyzed 128 publications, out of which 17 were included. Based on this systematic review, CEUS provides detailed data about fibroid volume and vascularization prior, during, and post UAE, and it helps determine the endpoint of the procedure. HIFUA with Intraprocedural CEUS has faster volume shrinkage over a shorter time period with less needed energy and provides early detection of residual tissue after HIFUA. CEUS and contrast-enhanced MRI (CE-MRI) have sufficient agreement to be used interchangeably in the clinic to evaluate the therapeutic effect of PMWA and HIFUA of fibroids.
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